This paper describes the application of ZIF-67 nanoparticles for carbon paste electrode (CPE) modification for sensitive voltammetric detection of mesalazine (MSA). The characterization of as-synthesized ZIF-67 nanoparticles was investigated by different techniques. Furthermore, the electrochemical behavior of the modified CPE (MCPE) was investigated using EIS (electrochemical impedance spectroscopy) and CV (cyclic voltammetry) methods. The results showed an irreversible oxidation peak for MSA around 0.540 V vs. the Ag/AgCl reference electrode. The curve of the peak current of differential pulse voltammetry (DPV) vs MSA concentration was linear in the range of 0.03–50 μM with a detection limit of 0.01 µM. The prepared sensor presents good repeatability with acceptable relative standard deviation (RSD) values. Finally, the prepared electrode was successfully used in human serum and urine as real samples.

本文介绍了ZIF-67纳米粒子在碳糊电极（CPE）修饰用于美沙拉嗪（MSA）灵敏伏安检测中的应用。通过不同技术研究了合成后的ZIF-67纳米粒子的表征。此外，使用EIS（电化学阻抗谱）和CV（循环伏安法）方法研究了改性CPE（MCPE）的电化学行为。结果显示，相对于Ag / AgCl参比电极，MSA的不可逆氧化峰约为0.540V。差分脉冲伏安法（DPV）的峰值电流与MSA浓度的关系曲线在0.03–50μM范围内呈线性，检出限为0.01 µM。制备的传感器具有良好的可重复性，具有可接受的相对标准偏差（RSD）值。最后，