ProTExA is a web-tool that provides a post-processing workflow for the analysis of protein and gene expression datasets. Using network-based bioinformatics approaches, ProTExA facilitates differential expression analysis and co-expression network analysis as well as pathway and post-pathway analysis. Specifically, for a given set of protein-gene expression data across samples, ProTExA: (1) performs statistical analysis and filtering to highlight the differentially expressed proteins-genes, (2) performs enrichment analysis to identify top-scored pathways, (3) generates pathway-to-pathway and pathway-to-gene networks (4) generates protein and gene co-expression networks using a variety of methodologies, and (5) applies clustering methodologies to identify sub-networks of co-expressed proteins-genes. The proposed web-tool is a simple yet informative tool, towards understanding and exploitation of protein and gene expression datasets, especially for those that do not have the expertise and local resources to replicate specific analyses in the context of collaborative and scientific data exchanging.

ProTExA是一个网络工具，可提供用于分析蛋白质和基因表达数据集的后处理工作流程。ProTExA使用基于网络的生物信息学方法，可以促进差异表达分析和共表达网络分析以及路径和路径后分析。具体来说，对于样本中一组给定的蛋白质基因表达数据集，ProTExA：（1）进行统计分析和过滤以突出显示差异表达的蛋白质-基因，（2）进行富集分析以鉴定得分最高的途径，（3）产生途径到途径和途径到基因网络（4）使用多种方法产生蛋白质和基因共表达网络，以及（5）应用聚类方法来鉴定共表达的蛋白质基因的子网络。