Anaerobes form a large part of microbial communities, and have begun to be specifically studied in both healthy and pathologic contexts. Porphyromonas is one of the top ten anaerobic taxa in the microbiome (anaerobiome) in healthy subjects. However, to date, most studies focused on the deleterious role of P. gingivalis, the most widely described species. Interestingly, targeted metagenomics reveals Porphyromonas other than gingivalis (POTG), highlighting other species such as P. catoniae or P. pasteri as potential biomarkers in disease progression or pathogen colonization susceptibility. From the sparse data, it appears that the Porphyromonas genus may also be a relevant target of investigation in several pulmonary diseases. Moreover, deciphering cutaneous, gastric and oral microbiomes hint that Porphyromonas may be a genus of interest in non-pulmonary diseases.

This review aims to summarize the major data on POTG and to report their impact on the various human microbiomes in different clinical states.

厌氧菌构成了微生物群落的很大一部分，并且已经开始在健康和病理环境中进行专门研究。卟啉单胞菌是健康受试者微生物组（anaerobiome）中排名前十的厌氧类群之一。然而，迄今为止，大多数研究都集中在牙龈卟啉单胞菌的有害作用上，牙龈卟啉单胞菌是描述最广泛的物种。有趣的是，靶向宏基因组学揭示了牙龈卟啉单胞菌(POTG)以外的卟啉单胞菌，突出了其他物种，如P. catoniae 或 P. pasteri作为疾病进展或病原体定植易感性的潜在生物标志物。从稀疏数据看来，卟啉单胞菌属也可能是几种肺部疾病的相关研究目标。此外，破译皮肤、胃和口腔微生物组暗示卟啉单胞菌可能是非肺部疾病的一个感兴趣的属。

本综述旨在总结 POTG 的主要数据，并报告它们对不同临床状态下各种人类微生物组的影响。