Five samples of hydroxyapatite (HAp) doped with praseodymium (Pr) at various amounts (2, 4, 6, 8, and 10 at.%) were synthesized by using the wet chemical route. The effects of Pr doping on the structural and thermal properties, as well as on the in vitro performance of HAp, were investigated experimentally. The band structure and density of states (DOS) of HAp were studied theoretically. Incorporation of Pr into the crystal lattice of HAp was observed. A gradual increase in the crystallite size, lattice parameter a, and unit cell volume was found, and a gradual decrease in the crystallinity degree was seen. Pr content from 2 to 10 at.% did not affect the thermal stability of HAp. The theoretical results showed that the bandgap energy of HAp decreased steadily from 3.82 to 1.32 eV with the adding of Pr, and the DOS was also affected by the Pr content. The cell viability tests showed that among all the as-synthesized samples, the best biocompatible properties were found for the sample which was doped with 10 at.% Pr, and the amount of Pr affected significantly the cell viability property of HAp. Except for the sample having 6 at.% Pr, all the remaining samples appeared to be potentially good candidates for biomedical applications.

通过使用湿化学路线合成了五种掺有各种含量（2、4、6、8和10 at。％）的ase（Pr）的羟磷灰石（HAp）样品。实验研究了Pr掺杂对结构和热性能以及HAp体外性能的影响。从理论上研究了HAp的能带结构和态密度（DOS）。观察到将Pr掺入HAp的晶格中。微晶尺寸，晶格参数a逐渐增加，并且发现晶胞体积，并且观察到结晶度逐渐降低。Pr含量为2至10 at。％不会影响HAp的热稳定性。理论结果表明，随着Pr的添加，HAp的带隙能从3.82 eV稳定下降到1.32 eV，DOS也受到Pr含量的影响。细胞活力测试表明，在所有合成样品中，掺有10 at。％Pr的样品均具有最佳的生物相容性，并且Pr的含量显着影响HAp的细胞活力。除了具有6 at。％Pr的样品外，所有其余样品似乎都是生物医学应用的潜在好候选者。