Abstract Five chalcone derivatives (E)-1-(2-(2-bromoethoxy)phenyl)-3-phenylprop-2-en-1-one( 1 ), (E)-1-(2-(3-bromopropoxy)phenyl)-3-phenylprop-2-en-1-one( 2 ),(E)-1-(2-(4-bromopropoxy)phenyl)-3-phenylprop-2-en-1-one( 3 ),(E)-1-(2-(5-bromopropoxy)phenyl)-3-phenylprop-2-en-1-one( 4 ),(E)-1-(2-(6-bromopropoxy)phenyl)-3-phenylprop-2-en-1-one( 5 ) were synthesized and characterized by 1 H NMR, HRMS. The crystalline structures of compounds 4 and 5 were further characterized by X-ray crystal diffraction. Among the five compounds, 1 and 2 showed inhibitory activity on α-glucosidase, but 4 and 5 increased the activity of α-glucosidase. Graphic Abstract Five chalcone derivatives were synthesized and characterized by 1 H MNR and HRMS. The crystalline structures of two compounds were further characterized by X-ray crystal diffraction. Two of the compounds have the ability to inhibit α-glucosidase, and two different compounds have the ability to promote α-glucosidase.

中文翻译：

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查耳酮衍生物的合成、晶体结构及其对α-葡萄糖苷酶的影响

摘要 五种查尔酮衍生物 (E)-1-(2-(2-bromoethoxy)phenyl)-3-phenylprop-2-en-1-one(1), (E)-1-(2-(3-bromopropoxy)苯基)-3-苯基丙-2-烯-1-酮(2)，(E)-1-(2-(4-溴丙氧基)苯基)-3-苯基丙-2-烯-1-酮(3)， (E)-1-(2-(5-溴丙氧基)苯基)-3-苯基丙-2-烯-1-one(4),(E)-1-(2-(6-溴丙氧基)苯基)-3 -phenylprop-2-en-1-one(5)被合成并通过1 H NMR、HRMS表征。通过X射线晶体衍射进一步表征了化合物4和5的晶体结构。5种化合物中，1和2对α-葡萄糖苷酶有抑制活性，4和5增加了α-葡萄糖苷酶的活性。图形摘要 合成了五种查耳酮衍生物，并通过 1 H MNR 和 HRMS 对其进行表征。通过X射线晶体衍射进一步表征了两种化合物的晶体结构。