A computational strategy based on the finite element method for simulating the mechanical response of arterial tissues is herein proposed. The adopted constitutive formulation accounts for rotations of the adventitial collagen fibers and introduces parameters which are directly measurable or well established. Moreover, the refined constitutive model is readily utilized in finite element analyses, enabling the simulation of mechanical tests to reveal the influence of microstructural and histological features on macroscopic material behavior. Employing constitutive parameters supported by histological examinations, the results herein validate the model’s ability to predict the micro- and macroscopic mechanical behavior, closely matching previously observed experimental findings. Finally, the capabilities of the adopted constitutive description are shown investigating the influence of some collagen disorders on the macroscopic mechanical response of the arterial tissues.

本文提出了一种基于有限元方法的计算策略，用于模拟动脉组织的机械响应。所采用的本构公式考虑了外膜胶原纤维的旋转，并引入了可直接测量或充分建立的参数。此外，精炼的本构模型很容易用于有限元分析，使力学测试模拟能够揭示微观结构和组织学特征对宏观材料行为的影响。采用组织学检查支持的本构参数，本文的结果验证了模型预测微观和宏观机械行为的能力，与先前观察到的实验结果密切匹配。最后，