Abstract: pH-sensitive hydrogels have been developed greatly over the past few years. This has been possible due to the synthesis of new hydrogel systems with increased sensitivity – a sensitivity of up to 10^{− 5} pH units has already been established. Recently, pH-sensitive hydrogels have shown to be very useful in biomedical applications, such as targeted cancer treatment and treatment of skin lesions. Prolonged drug release has been made available through the use of such hydrogels. The synthesis of pH-sensitive hydrogels is also quick and cost-effective. This review presents a background on the properties of pH-sensitive hydrogels and discusses some of the hydrogels with different sensitivity ranges and their possible applications. A range of synthesis processes have also been briefly introduced along with the fabrication of different structures such as microcantilevers and contact lenses.

Keywords: pH-sensitive, sensors, hydrogels, biomedical applications, biocompatible


中文翻译：

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pH敏感的基于水凝胶的设备的医疗保健应用：综述。

摘要：近年来，对pH敏感的水凝胶得到了很大的发展。这一直是可能的，因为新的水凝胶体系具有提高的灵敏度的合成-向上的灵敏度到10 ^{- 5}pH单位已经建立。近来，已经显示出pH敏感的水凝胶在生物医学应用中非常有用，例如靶向癌症治疗和皮肤损伤的治疗。通过使用这种水凝胶可以延长药物的释放时间。pH敏感水凝胶的合成也快速且具有成本效益。这篇综述介绍了pH敏感水凝胶的性质，并讨论了一些具有不同灵敏度范围的水凝胶及其可能的应用。还简要介绍了一系列合成过程以及不同结构（如微悬臂梁和隐形眼镜）的制造。

关键字： pH敏感，传感器，水凝胶，生物医学应用，生物相容性