Today, an advanced wound dressing with the ability of blood clotting and antibacterial activity is the main subject of many studies to consider their necessity in modern society. In this study, it was aimed to present a novel scaffold with both abilities simultaneously. Poly(vinyl alcohol)/poly(lactic acid) nanofibrous scaffolds containing ceftriaxone antimicrobial agent (PVA-CTX/PLA) and tranexamic acid coagulant (PVA-CTX-TXA/PLA) were fabricated by electrospinning method. Morphology, antimicrobial activity, blood coagulation and bioavailability indexes, and swelling ability (gel formation) of produced samples were determined. Morphological results showed that the hybrid nanofibers were form successfully. The antibacterial efficiency of them against Gram-negative (Escherichia coli) and Gram-positive (Staphylococcus aureus) bacteria was more than 90% for PVA-CTX/PLA and it reached 100% for PVA-CTX-TXA/PLA. Both PVA-CTX-TXA/PLA and PVA-TXA/PLA scaffolds showed acceptable blood coagulation ability with an average absorption of 0.043 and 0.036 nm, respectively. PVA-CTX-TXA/PLA scaffolds had a gel formation ability of about 45 min. All scaffolds were successful in cell proliferation (L929 fibroblast cell) after 48 h.

中文翻译：

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基于聚（乙烯醇）/聚（乳酸）的新型止血剂和抗菌纳米纤维支架

今天，具有凝血能力和抗菌活性的先进伤口敷料是许多研究的主要主题，以考虑其在现代社会中的必要性。在这项研究中，旨在展示一种同时具有两种能力的新型支架。采用静电纺丝法制备了含有头孢曲松抗菌剂（PVA-CTX/PLA）和氨甲环酸凝固剂（PVA-CTX-TXA/PLA）的聚（乙烯醇）/聚（乳酸）纳米纤维支架。测定了制备的样品的形态、抗菌活性、凝血和生物利用度指标以及溶胀能力（凝胶形成）。形态学结果表明混合纳米纤维已成功形成。它们对革兰氏阴性（大肠杆菌）和革兰氏阳性（金黄色葡萄球菌）细菌的抗菌效率对 PVA-CTX/PLA 均超过 90%，对 PVA-CTX-TXA/PLA 达到 100%。PVA-CTX-TXA/PLA 和 PVA-TXA/PLA 支架均显示出可接受的凝血能力，平均吸收分别为 0.043 和 0.036 nm。PVA-CTX-TXA/PLA 支架具有约 45 分钟的凝胶形成能力。所有支架在 48 小时后细胞增殖（L929 成纤维细胞）均成功。