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Immunologic aspects of characteristics, diagnosis, and treatment of coronavirus disease 2019 (COVID-19)
Journal of Biomedical Science ( IF 11.0 ) Pub Date : 2020-06-04 , DOI: 10.1186/s12929-020-00663-w
Feng-Yee Chang , Hsiang-Cheng Chen , Pei-Jer Chen , Mei-Shang Ho , Shie-Liang Hsieh , Jung-Chung Lin , Fu-Tong Liu , Huey-Kang Sytwu

On March 11, 2020, the World Health Organization declared the worldwide spread of the infectious disease COVID-19, caused by a new strain of coronavirus, SARS-CoV-2, as a pandemic. Like in all other infectious diseases, the host immune system plays a key role in our defense against SARS-CoV-2 infection. However, viruses are able to evade the immune attack and proliferate and, in susceptible individuals, cause severe inflammatory response known as cytokine storm, particularly in the lungs. The advancement in our understanding of the mechanisms underlying the host immune responses promises to facilitate the development of approaches for prevention or treatment of diseases. Components of immune system, such as antibodies, can also be used to develop sensitive and specific diagnostic methods as well as novel therapeutic agents. In this review, we summarize our knowledge about how the host mounts immune responses to infection by SARS-CoV-2. We also describe the diagnostic methods being used for COVID-19 identification and summarize the current status of various therapeutic strategies, including vaccination, being considered for treatment of the disease.

中文翻译:

冠状病毒病2019(COVID-19)的特征,诊断和治疗的免疫学方面

2020年3月11日,世界卫生组织宣布由新型冠状病毒SARS-CoV-2引起的传染病COVID-19在世界范围内传播为大流行。像所有其他传染病一样,宿主免疫系统在我们防御SARS-CoV-2感染中起着关键作用。然而,病毒能够逃避免疫攻击并增殖,并且在易感个体中引起严重的炎症反应,称为细胞因子风暴,特别是在肺部。我们对宿主免疫应答基础机制的了解的进步有望促进疾病预防或治疗方法的发展。免疫系统的成分,例如抗体,也可以用于开发敏感和特异性的诊断方法以及新型治疗剂。在这篇评论中 我们总结了有关宿主如何对SARS-CoV-2感染产生免疫反应的知识。我们还描述了用于COVID-19识别的诊断方法,并总结了考虑用于疾病治疗的各种治疗策略(包括疫苗接种)的当前状态。
更新日期:2020-07-01
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