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Signaling in and out: long-noncoding RNAs in tumor hypoxia
Journal of Biomedical Science ( IF 11.0 ) Pub Date : 2020-05-05 , DOI: 10.1186/s12929-020-00654-x Tse-Chun Kuo , Hsing-Jien Kung , Jing-Wen Shih
Journal of Biomedical Science ( IF 11.0 ) Pub Date : 2020-05-05 , DOI: 10.1186/s12929-020-00654-x Tse-Chun Kuo , Hsing-Jien Kung , Jing-Wen Shih
Over the past few years, long non-coding RNAs (lncRNAs) are recognized as key regulators of gene expression at chromatin, transcriptional and posttranscriptional level with pivotal roles in various biological and pathological processes, including cancer. Hypoxia, a common feature of the tumor microenvironment, profoundly affects gene expression and is tightly associated with cancer progression. Upon tumor hypoxia, the central regulator HIF (hypoxia-inducible factor) is upregulated and orchestrates transcription reprogramming, contributing to aggressive phenotypes in numerous cancers. Not surprisingly, lncRNAs are also transcriptional targets of HIF and serve as effectors of hypoxia response. Indeed, the number of hypoxia-associated lncRNAs (HALs) identified has risen sharply, illustrating the expanding roles of lncRNAs in hypoxia signaling cascade and responses. Moreover, through extra-cellular vesicles, lncRNAs could transmit hypoxia responses between cancer cells and the associated microenvironment. Notably, the aberrantly expressed cellular or exosomal HALs can serve as potential prognostic markers and therapeutic targets. In this review, we provide an update of the current knowledge about the expression, involvement and potential clinical impact of lncRNAs in tumor hypoxia, with special focus on their unique molecular regulation of HIF cascade and hypoxia-induced malignant progression.
中文翻译:
信号输入和输出:肿瘤缺氧中的长非编码RNA
在过去的几年中,长的非编码RNA(lncRNA)被认为是染色质,转录和转录后水平上基因表达的关键调节剂,在包括癌症在内的各种生物学和病理学过程中起着关键作用。缺氧是肿瘤微环境的共同特征,深刻影响基因表达,并与癌症进展密切相关。在肿瘤缺氧时,中央调节因子HIF(缺氧诱导因子)被上调并协调转录重编程,从而在许多癌症中导致侵袭性表型。毫不奇怪,lncRNAs也是HIF的转录靶点,并充当缺氧反应的效应子。实际上,已确定的与缺氧相关的lncRNA(HAL)数量急剧增加,说明了lncRNA在缺氧信号级联和反应中的扩展作用。此外,通过细胞外小泡,lncRNA可以在癌细胞与相关微环境之间传递缺氧反应。值得注意的是,异常表达的细胞或外泌体HAL可以作为潜在的预后标志物和治疗靶标。在这篇综述中,我们提供了有关lncRNA在肿瘤缺氧中的表达,参与和潜在临床影响的最新知识的更新,特别关注它们对HIF级联和缺氧诱导的恶性进展的独特分子调控。异常表达的细胞或外泌体HAL可以作为潜在的预后标志物和治疗靶标。在这篇综述中,我们提供了有关lncRNA在肿瘤缺氧中的表达,参与和潜在临床影响的最新知识的更新,特别关注它们对HIF级联和缺氧诱导的恶性进展的独特分子调控。异常表达的细胞或外泌体HAL可以作为潜在的预后标志物和治疗靶标。在这篇综述中,我们提供了有关lncRNA在肿瘤缺氧中的表达,参与和潜在临床影响的最新知识的更新,特别关注它们对HIF级联和缺氧诱导的恶性进展的独特分子调控。
更新日期:2020-07-01
中文翻译:
信号输入和输出:肿瘤缺氧中的长非编码RNA
在过去的几年中,长的非编码RNA(lncRNA)被认为是染色质,转录和转录后水平上基因表达的关键调节剂,在包括癌症在内的各种生物学和病理学过程中起着关键作用。缺氧是肿瘤微环境的共同特征,深刻影响基因表达,并与癌症进展密切相关。在肿瘤缺氧时,中央调节因子HIF(缺氧诱导因子)被上调并协调转录重编程,从而在许多癌症中导致侵袭性表型。毫不奇怪,lncRNAs也是HIF的转录靶点,并充当缺氧反应的效应子。实际上,已确定的与缺氧相关的lncRNA(HAL)数量急剧增加,说明了lncRNA在缺氧信号级联和反应中的扩展作用。此外,通过细胞外小泡,lncRNA可以在癌细胞与相关微环境之间传递缺氧反应。值得注意的是,异常表达的细胞或外泌体HAL可以作为潜在的预后标志物和治疗靶标。在这篇综述中,我们提供了有关lncRNA在肿瘤缺氧中的表达,参与和潜在临床影响的最新知识的更新,特别关注它们对HIF级联和缺氧诱导的恶性进展的独特分子调控。异常表达的细胞或外泌体HAL可以作为潜在的预后标志物和治疗靶标。在这篇综述中,我们提供了有关lncRNA在肿瘤缺氧中的表达,参与和潜在临床影响的最新知识的更新,特别关注它们对HIF级联和缺氧诱导的恶性进展的独特分子调控。异常表达的细胞或外泌体HAL可以作为潜在的预后标志物和治疗靶标。在这篇综述中,我们提供了有关lncRNA在肿瘤缺氧中的表达,参与和潜在临床影响的最新知识的更新,特别关注它们对HIF级联和缺氧诱导的恶性进展的独特分子调控。