The effects of intravenous immunoglobulin G replacement on perceived health and infection susceptibility of patients suffering from immunoglobulin G (IgG) deficiencies should be evaluated in a prospective analysis. Patients with symptomatic primary or secondary IgG deficiencies were interviewed prior to the first IgG infusion (t0) and over the course of their treatment (t1 - t6). The respondents rated their current health using a 100 point scale (EQ-5D-5L), ranging from 0 (‘worst imaginable health’) to 100 (‘best imaginable health’). The patients also provided information on the frequency of infections and of infections requiring antibiotics in the past 8 weeks. A healthy control group (CG) without oncologic diseases answered the questions once. One hundred six patients with a median age of 65 years (21–85 years) were investigated. The median serum IgG concentration changed from 500 mg/dl (t0) to 772 mg/dl (t6). The mean number of infections and of infections requiring antibiotics decreased during IgG replacement significantly. Current health according to EQ-5D-5L improved from 57 (t0) to 68 (t6), compared to 73 in the CG. During the course of IgG replacement patients reported fewer and less severe infections. Their health assessment improved but still was inferior to the healthy CG.

中文翻译：

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接受静脉 IgG 替代治疗的有症状的原发性和继发性免疫球蛋白 G (IgG) 缺乏症患者的健康状况和感染。

应在前瞻性分析中评估静脉注射免疫球蛋白 G 替代品对免疫球蛋白 G (IgG) 缺乏症患者的感知健康和感染易感性的影响。在第一次 IgG 输注之前 (t0) 和在他们的治疗过程中 (t1 - t6) 采访了有症状的原发性或继发性 IgG 缺陷的患者。受访者使用 100 分制 (EQ-5D-5L) 对他们当前的健康状况进行评分，范围从 0（“可想象的最差健康”）到 100（“可想象的最佳健康”）。患者还提供了过去 8 周内感染频率和需要抗生素治疗的感染频率的信息。没有肿瘤疾病的健康对照组 (CG) 回答了一次问题。研究了 106 名中位年龄为 65 岁（21-85 岁）的患者。中值血清 IgG 浓度从 500 mg/dl (t0) 变为 772 mg/dl (t6)。在 IgG 替代期间，感染和需要抗生素的感染平均数显着减少。根据 EQ-5D-5L 的当前健康从 57 (t0) 提高到 68 (t6)，而 CG 中的为 73。在 IgG 替代治疗过程中，患者报告的感染越来越少。他们的健康评估有所改善，但仍不如健康的 CG。