We elucidate two annealing assisted mechanochemical methods to achieve one-pot encapsulation of anti-cancer drug 5-fluorouracil (5-FU) in the iron-based MIL-100 metal–organic framework (MOF). We compare the structural and physicochemical properties of drug@MIL-100 systems derived from in situ manual and vortex grinding, where the former technique exhibits a slower drug release due to stronger guest–host interactions.

中文翻译：

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机械化学方法可在MIL-100（Fe）金属-有机框架内原位限制5-FU抗癌药物

我们阐明了两种退火辅助机械化学方法，以在铁基MIL-100金属-有机骨架（MOF）中实现一锅法封装抗癌药物5-氟尿嘧啶（5-FU）。我们比较了原位人工和涡流研磨衍生的drug @ MIL-100系统的结构和物理化学特性，其中前一种技术由于较强的来宾-宿主相互作用而显示出较慢的药物释放。