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Cenostigma macrophyllum Tul. var. acuminata Teles Freire Fraction Leaves Stimulate Gastric Healing in Rats and Human Cell Cultures
Journal of Medicinal Food ( IF 2.4 ) Pub Date : 2021-03-16 , DOI: 10.1089/jmf.2020.0013 Ana Flávia Seraine Custódio Viana 1 , Hélio B Fernandes 1 , Mariana H Chaves 2 , Daniel A Viana 3 , Verlane G Santos 4 , Ariadne C A Silva 4 , Miriam T P Lopes 4 , Rita de Cássia M Oliveira 1
Journal of Medicinal Food ( IF 2.4 ) Pub Date : 2021-03-16 , DOI: 10.1089/jmf.2020.0013 Ana Flávia Seraine Custódio Viana 1 , Hélio B Fernandes 1 , Mariana H Chaves 2 , Daniel A Viana 3 , Verlane G Santos 4 , Ariadne C A Silva 4 , Miriam T P Lopes 4 , Rita de Cássia M Oliveira 1
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Cenostigma macrophyllum Tul. var. acuminata Teles Freire (Leguminosae–Caesalpinioideae) is a medicinal plant traditionally used for treatment of gastric ulcer. This study evaluated the ulcer-healing activity of the hydroalcoholic fraction of C. macrophyllum Tul. var. acuminata Teles Freire leaves (Cm-FHA) and the tea of the leaves of C. macrophyllum (Cm-tea), as well as the possible action of Cm-FHA, through in vitro models. Leaves of C. macrophyllum were dried and powdered to obtain the Cm-FHA. Subsequently, the Cm-FHA was characterized phytochemically and biologically. Besides, Cm-tea was prepared. The gastric healing effects of Cm-tea and Cm-FHA were analyzed using the model of acetic acid-induced gastric ulcer in rats. The human gastric adenocarcinoma (AGS) cell line was employed as an in vitro model. Cm-tea promoted a protective effect against gastric ulcers induced by absolute ethanol. Cm-FHA or Cm-tea (100 mg/kg/7 days) exhibited a significant healing effect on ulcers induced by acetic acid. In the histological analysis, gastric mucosa treated with Cm-FHA or Cm-tea advanced restoration of the mucosal epithelium. In vitro, lower concentrations of Cm-FHA stimulated cell proliferation in the BrdU assay and cell migration. Cm-tea and Cm-FHA present a significant gastric healing effect in in vivo and in vitro models.
中文翻译:
Cenostigma macrophyllum Tul。变种。acuminata Teles Freire 分数叶刺激大鼠和人类细胞培养中的胃愈合
Cenostigma macrophyllum Tul。变种。acuminata Teles Freire (Leguminosae-Caesalpinioideae) 是一种传统上用于治疗胃溃疡的药用植物。本研究评估了C. macrophyllum Tul的水醇部分的溃疡愈合活性。变种。acuminata Teles Freire 叶 ( Cm -FHA) 和C. macrophyllum叶茶( Cm -tea),以及Cm -FHA 可能的作用,通过体外模型。将C. macrophyllum的叶子干燥并制成粉末以获得Cm -FHA。随后,厘米-FHA 具有植物化学和生物学特征。此外,还准备了Cm茶。采用醋酸致大鼠胃溃疡模型分析Cm-tea和Cm-FHA的胃愈合作用。人胃腺癌细胞(AGS)细胞系被用作体外模型。Cm -tea 对无水乙醇引起的胃溃疡具有保护作用。Cm -FHA 或Cm -tea (100 mg/kg/7 天) 对醋酸引起的溃疡有显着的愈合作用。在组织学分析中,用Cm -FHA 或Cm处理的胃黏膜-茶先进的粘膜上皮修复。在体外,较低浓度的Cm -FHA 在 BrdU 测定中刺激细胞增殖和细胞迁移。Cm -tea 和Cm -FHA在体内和体外模型中表现出显着的胃愈合作用。
更新日期:2021-03-21
中文翻译:
Cenostigma macrophyllum Tul。变种。acuminata Teles Freire 分数叶刺激大鼠和人类细胞培养中的胃愈合
Cenostigma macrophyllum Tul。变种。acuminata Teles Freire (Leguminosae-Caesalpinioideae) 是一种传统上用于治疗胃溃疡的药用植物。本研究评估了C. macrophyllum Tul的水醇部分的溃疡愈合活性。变种。acuminata Teles Freire 叶 ( Cm -FHA) 和C. macrophyllum叶茶( Cm -tea),以及Cm -FHA 可能的作用,通过体外模型。将C. macrophyllum的叶子干燥并制成粉末以获得Cm -FHA。随后,厘米-FHA 具有植物化学和生物学特征。此外,还准备了Cm茶。采用醋酸致大鼠胃溃疡模型分析Cm-tea和Cm-FHA的胃愈合作用。人胃腺癌细胞(AGS)细胞系被用作体外模型。Cm -tea 对无水乙醇引起的胃溃疡具有保护作用。Cm -FHA 或Cm -tea (100 mg/kg/7 天) 对醋酸引起的溃疡有显着的愈合作用。在组织学分析中,用Cm -FHA 或Cm处理的胃黏膜-茶先进的粘膜上皮修复。在体外,较低浓度的Cm -FHA 在 BrdU 测定中刺激细胞增殖和细胞迁移。Cm -tea 和Cm -FHA在体内和体外模型中表现出显着的胃愈合作用。