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Formation of 1-Hydroxymethylene-1,1-bisphosphinates through the Addition of a Silylated Phosphonite on Various Trivalent Derivatives.
The Journal of Organic Chemistry ( IF 3.6 ) Pub Date : 2020-06-29 , DOI: 10.1021/acs.joc.0c01182
Jade Dussart-Gautheret 1 , Julia Deschamp 1 , Maelle Monteil 1 , Olivier Gager 1 , Thibaut Legigan 1 , Evelyne Migianu-Griffoni 1 , Marc Lecouvey 1
Affiliation  

An easily handled one-pot synthetic procedure was previously developed for the synthesis of bisphosphinates starting from acyl chlorides. Herein, other trivalent derivatives as acid anhydrides and activated esters were tested to form various bisphosphinates. This modulation of the reactivity can be controlled according to the nature of the acid derivative for the use of sensitive and functionalized substrates.

中文翻译:

通过在各种三价衍生物上添加甲硅烷基化的亚膦酸酯,形成1-羟基亚甲基-1,1-二次膦酸酯。

先前已经开发了一种易于处理的一锅合成方法,用于从酰氯开始合成双膦酸酯。本文中,测试了作为酸酐和活化酯的其他三价衍生物以形成各种双次膦酸酯。可以根据酸衍生物的性质来控制反应性的这种调节,以用于敏感的和功能化的底物。
更新日期:2020-06-29
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