Abstract

Background

Y-chromosomal short tandem repeats (Y-STRs) are widely used in paternity identification, pedigree investigation, and human population genetic history.

Aim

To investigate the Y-STR polymorphisms in a typical Miao population, and explore the genetic differentiation between the Miao population and reference groups.

Subjects and methods

We detected 36 Y-STRs genotyping in 455 unrelated Miao individuals from Guizhou province, and analysed genetic differentiation between the Miao population and 76 reference groups.

Results

A total of 369 alleles were obtained, and the allele frequencies ranged from 0.0022 to 0.9802. In addition, the haplotype diversity, random match probability, and discrimination capacity values were 0.99997, 0.0022, and 0.9934, respectively. Moreover, the genetic relationships between Guizhou Miao and 76 ethnic populations showed that the population stratification was almost consistent with geographic distribution and language-family.

Conclusions

The 36 Y-STR loci in this study have good polymorphism distributions in the Guizhou Miao population, and therefore would be a useful tool in forensic identification and male parentage testing and even pedigree investigation.

中文翻译：

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苗族苗族苗族中36个Y染色体STR基因座的遗传结构和法医鉴定。

摘要

背景

Y染色体短串联重复序列（Y-STR）广泛用于亲子鉴定，系谱研究和人群遗传史。

目标

调查典型的苗族人群中的Y-STR多态性，并探讨苗族和参考人群之间的遗传差异。

主题与方法

我们在贵州省455名无关的苗族个体中检测到36个Y-STRs基因型，并分析了苗族与76个参考群体之间的遗传分化。

结果

共获得369个等位基因，等位基因频率在0.0022至0.9802之间。此外，单倍型多样性，随机匹配概率和区分能力值分别为0.99997、0.0022和0.9934。此外，贵州苗族与76个民族的遗传关系表明，人口分层几乎与地理分布和语言家庭一致。

结论

本研究中的36个Y-STR位点在贵州苗族人群中具有良好的多态性分布，因此将成为法医鉴定，男性亲子鉴定甚至系谱研究的有用工具。