ABSTRACT

Introduction

Oral delivery is the most common administrated drug delivery path. However, oral administration of lipophilic drugs has some limitations: they have poor dose-response due to low and varied dissolution kinetics and oral bioavailability with sub-optimal dissolution within the aqueous gastrointestinal microenvironment. Therefore, there is a need for robust formulating methods that protect the drug until it reaches to its optimum absorption site, allowing its optimum pharmacological effects via increasing its intestinal permeation and bioavailability.

Area covered

Herein, we provide insights on orally administered lipophilic drug delivery systems. The detailed description of the obstacles associated with the oral bioavailability of lipophilic drugs are also discussed. Following this, techniques to overcome these obstacles with much emphasis on optimal safety and efficacy are addressed. Newly designed ionic vibrational jet flow encapsulation technology has enormous growth in lipophilic drug delivery systems, which is discussed thereafter.

Expert opinion

Researchers have shown interest in drug’s encapsulation. A combination of drug-bile acid and microencapsulation methods can be one promising strategy to improve the oral delivery of lipophilic drugs. However, the most critical aspect of this approach is the selection of bile acids, polymer, and encapsulation technology.

中文翻译：

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使用生物微/纳米封装技术的基于藻酸盐的药物口服靶向。

摘要

介绍

口服给药是最常见的给药途径。但是，亲脂性药物的口服给药有一些局限性：由于低和变化的溶出动力学和口服生物利用度，在水性胃肠道微环境中的溶出度不佳，它们的剂量反应较差。因此，需要鲁棒的配制方法来保护药物直至其达到最佳吸收位点，从而通过增加其肠渗透性和生物利用度来实现其最佳药理作用。

覆盖面积

在本文中，我们提供了口服亲脂药物递送系统的见解。还讨论了与亲脂性药物口服生物利用度相关的障碍的详细说明。此后，提出了克服这些障碍的技术，其中特别强调了最佳的安全性和有效性。新设计的离子振动射流封装技术在亲脂药物递送系统中有了巨大的发展，此后将进行讨论。

专家意见

研究人员对药物的封装表现出了兴趣。胆汁酸和微囊化方法的结合可能是改善亲脂性药物口服给药的一种有前途的策略。但是，这种方法最关键的方面是胆汁酸，聚合物和封装技术的选择。