Abstract The aim of this study was to investigate the effects of extracts and pure Artemisia dracunculus L. (tarragon) metabolites on the antimonoamine oxidase and anticholinesterase activities. The compounds were characterized as stigmasterol (1), herniarin (2), (2E,4E)-1-(piperidin-1-yl)undeca-2,4-diene-8,10-diyn-1-one (3), (2E,4E)-N-isobutylundeca-2,4-dien-8,10-diynamide (4), 3,4-dehydroherniarin (5) and skimmin (6) by 1H-NMR, 13C-NMR, 1D and 2D NMR methods. The compounds 5 and 6 were isolated from tarragon for the first time. The extracts and pure compounds have inhibitory effects on the human monoamine oxidase (hMAO) A and B enzymes, whereas they did not exhibit any anticholinesterase activities. Among the tarragon compounds, only 2 and 6 compounds showed the inhibitory effects against hMAO A (IC50 = 51.76 and 73.47 μM, respectively) and hMAO B (IC50 = 0.84 and 1.63 mM, respectively). In the study, herniarin content in the extracts was also analysed by high-performance liquid chromatography and it was found that there was a relationship between the inhibition effects of the extracts and their herniarin content.

中文翻译：

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来自 Artemisia dracunculus L. herniarin 和skimmin 的人单胺氧化酶 (hMAO) A 和 hMAO B 抑制剂：来自 A. dracunculus L. 的人单胺氧化酶 A 和 B 抑制剂。

摘要 本研究的目的是研究提取物和纯蒿属植物（龙蒿）代谢物对抗单胺氧化酶和抗胆碱酯酶活性的影响。化合物的特征为豆甾醇 (1)、疝气素 (2)、(2E,4E)-1-(piperid-1-yl)undeca-2,4-diene-8,10-diyn-1-one (3) , (2E,4E)-N-isobutylundeca-2,4-dien-8,10-diynamide (4), 3,4-dehydroherniarin (5) 和skimmin (6) 通过 1H-NMR, 13C-NMR, 1D 和二维核磁共振方法。化合物5和6为首次从龙蒿中分离得到。提取物和纯化合物对人单胺氧化酶 (hMAO) A 和 B 酶具有抑制作用，而它们没有表现出任何抗胆碱酯酶活性。在龙蒿化合物中，只有 2 和 6 种化合物显示出对 hMAO A 的抑制作用（IC50 = 51.76 和 73.47 μM，分别）和 hMAO B（IC50 分别为 0.84 和 1.63 mM）。在研究中，还通过高效液相色谱分析了提取物中的herniarin含量，发现提取物的抑制作用与其herniarin含量之间存在关系。