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Fam70A binds Wnt5a to regulate meiosis and quality of mouse oocytes
Cell Proliferation ( IF 8.5 ) Pub Date : 2020-05-11 , DOI: 10.1111/cpr.12825
Na‐Na Zhang 1 , Teng Zhang 2 , Wen‐Yi Gao 1 , Xin Wang 1 , Zi‐Bin Wang 3 , Jin‐Yang Cai 1 , Yang Ma 4 , Cong‐Rong Li 1 , Xi‐Chen Chen 3 , Wen‐Tao Zeng 5 , Fan Hu 1 , Jian‐Min Li 5 , Zhi‐Xia Yang 1 , Chun‐Xiang Zhou 6 , Dong Zhang 1, 5
Affiliation  

Little is known about the roles of integral membrane proteins beyond channels, carriers or receptors in meiotic oocytes. The transmembrane protein Fam70A was previously identified as a likely “female fertility factor” in Fox3a‐knockout mouse ovaries where almost all follicles underwent synchronous activation and the mice became infertile very early. However, whether Fam70A functions in oocyte meiosis remains unknown. Therefore, the present study aimed to address this question.

中文翻译:

Fam70A 结合 Wnt5a 调节小鼠卵母细胞的减数分裂和质量

对于减数分裂卵母细胞中通道、载体或受体之外的整合膜蛋白的作用知之甚少。跨膜蛋白 Fam70A 先前被确定为可能是 Fox3a 基因敲除小鼠卵巢中的“女性生育因子”,其中几乎所有的卵泡都经历了同步激活,小鼠很早就变得不育。然而,Fam70A 是否在卵母细胞减数分裂中起作用仍然未知。因此,本研究旨在解决这个问题。
更新日期:2020-05-11
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