BCL2 family proteins have been widely studied over the past decade due to their essential roles in apoptosis, oncogenesis and anti‐cancer therapy. However, the similarities and differences in the spatial pattern of the BCL2 gene family within the context of chromatin have not been well characterized. We sought to fill this knowledge gap by assessing correlations between gene alteration, gene expression, chromatin accessibility, and clinical outcomes in gynaecologic and breast cancer.

中文翻译：

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B细胞淋巴瘤2家族基因在妇科和乳腺癌中显示出时空异质性的分子模式

由于 BCL2 家族蛋白在细胞凋亡、肿瘤发生和抗癌治疗中的重要作用，它们在过去十年中得到了广泛研究。然而，染色质背景下 BCL2 基因家族空间模式的异同尚未得到很好的表征。我们试图通过评估基因改变、基因表达、染色质可及性以及妇科和乳腺癌临床结果之间的相关性来填补这一知识空白。