Advanced glycation end products inhibit the osteogenic differentiation potential of adipose‐derived stem cells by modulating Wnt/β‐catenin signalling pathway via DNA methylation,Cell Proliferation

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Advanced glycation end products inhibit the osteogenic differentiation potential of adipose‐derived stem cells by modulating Wnt/β‐catenin signalling pathway via DNA methylation
Cell Proliferation ( IF 8.5 ) Pub Date : 2020-05-28 , DOI: 10.1111/cpr.12834
Yong Li _{1,

2} , Lang Wang _{1,

2,

3} , Maorui zhang ₃ , Kui Huang ₁ , Zhihao Yao ₁ , Pengcheng Rao ₁ , Xiaoxiao Cai ₂ , Jingang Xiao _{1,

3,

4,

5}

Affiliation

Advanced glycation end products (AGEs) are considered a cause of diabetic osteoporosis. Although adipose‐derived stem cells (ASCs) are widely used in the research of bone regeneration, the mechanisms of the osteogenic differentiation of ASCs from diabetic osteoporosis model remain unclear. This work aimed to investigate the influence and the molecular mechanisms of AGEs on the osteogenic potential of ASCs.

中文翻译：

高级糖基化终产物通过 DNA 甲基化调节 Wnt/β-catenin 信号通路抑制脂肪干细胞的成骨分化潜能

晚期糖基化终产物 (AGEs) 被认为是糖尿病性骨质疏松症的一个原因。尽管脂肪源性干细胞（ASCs）被广泛用于骨再生研究，但糖尿病骨质疏松模型中ASCs成骨分化的机制尚不清楚。这项工作旨在研究AGEs对ASCs成骨潜力的影响和分子机制。

更新日期：2020-05-28

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