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Structure-Based Design of Fluorogenic Substrates Selective for Human Proteasome Subunits.
ChemBioChem ( IF 3.2 ) Pub Date : 2020-06-29 , DOI: 10.1002/cbic.202000375
Elmer Maurits 1 , Christian G Degeling 1 , Alexei F Kisselev 2 , Bogdan I Florea 1 , Herman S Overkleeft 1
Affiliation  

Selective reporting: A set of fluorogenic substrates for each of the human proteasome subunits was reverse designed based on selective proteasome inhibitors. Assays on both cell lysates and purified proteasome were conducted and revealed high selectivity could be maintained.
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中文翻译:

对人蛋白酶体亚基有选择性的荧光底物的基于结构的设计。

选择性报道:基于选择性蛋白酶体抑制剂,反向设计了每个人类蛋白酶体亚基的一组荧光底物。进行了细胞裂解物和纯化的蛋白酶体的测定,发现可以保持高选择性。
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更新日期:2020-06-29
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