Using a non-integrative reprogramming method, a human iPSC Line, ZZUNEUi002-A, was generated from a 22-year-old male patient with spinocerebellar ataxia type 3 /Machado-Joseph disease (SCA3/MJD). This cell line shows pluripotency both in vitro and vivo, and has a normal karyotype. The iPSC line could be used as a tool for mechanism researching and drug screening.

中文翻译：

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从患有3型脊髓小脑共济失调的患者中产生无整合诱导多能干细胞（iPSC）系（ZZUNEUi002-A）。

使用非整合重编程方法，从22岁患有3型脊髓小脑共济失调/马查多-约瑟夫病（SCA3 / MJD）的男性患者中产生了人iPSC系ZZUNEUi002-A。该细胞系在体外和体内均显示多能性，并具有正常的核型。iPSC系列可以用作机制研究和药物筛选的工具。