Induced pluripotent stem cell (iPSC) line HUi001-A was reprogrammed from skin fibroblasts via non-integrating, virus free self-replicating RNA. Skin fibroblasts from an 81-year-old female Caucasian familial Alzheimer’s disease patient of Volga German family carrying N141I mutation in the PSEN2 gene (familial AD4, clinical summary confirmed Alzheimer’s disease) was obtained from the Coriell Institute (AG09908). Generated iPSCs were characterized and pluripotency was confirmed.

中文翻译：

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使用无整合非病毒方法从患有PSEN2 N141I突变的阿尔茨海默氏病患者中产生人诱导的多能干细胞系。

通过非整合的，无病毒的自我复制RNA，从皮肤成纤维细胞中重新编程诱导多能干细胞（iPSC）系HUi001-A。一位来自Volga德国家庭的81岁女性白种人家族性阿尔茨海默氏病患者的皮肤成纤维细胞是从Coriell研究所（AG09908）获得的，该患者在PSEN2基因中带有N141I突变（家族性AD4，临床摘要证实是阿尔茨海默氏病）。表征生成的iPSC，并确认了多能性。