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Synthesis of bioactive glass-based coating by plasma electrolytic oxidation: Untangling a new deposition pathway toward titanium implant surfaces.
Journal of Colloid and Interface Science ( IF 9.9 ) Pub Date : 2020-06-29 , DOI: 10.1016/j.jcis.2020.06.102
Raphael C Costa 1 , João G S Souza 1 , Jairo M Cordeiro 1 , Martinna Bertolini 2 , Erica D de Avila 3 , Richard Landers 4 , Elidiane C Rangel 5 , Carlos A Fortulan 6 , Belén Retamal-Valdes 7 , Nilson C da Cruz 5 , Magda Feres 7 , Valentim A R Barão 1
Affiliation  

Hypothesis

Although bioactive glass (BG) particle coatings were previously developed by different methods, poor particle adhesion to surfaces and reduced biological effects because of glass crystallization have limited their biomedical applications. To overcome this problem, we have untangled, for the first time, plasma electrolytic oxidation (PEO) as a new pathway for the synthesis of bioactive glass-based coating (PEO-BG) on titanium (Ti) materials.

Experiments

Electrolyte solution with bioactive elements (Na2SiO3-5H2O, C4H6O4Ca, NaNO3, and C3H7Na2O6P) was used as a precursor source to obtain a 45S5 bioglass-like composition on a Ti surface by PEO. Subsequently, the PEO-BG coating was investigated with respect to its surface, mechanical, tribological, electrochemical, microbiological, and biological properties, compared with those of machined and sandblasted/acid-etched control surfaces.

Findings

PEO treatment produced a coating with complex surface topography, Ti crystalline phases, superhydrophilic status, chemical composition, and oxide layer similar to that of 45S5-BG (~45.0Si, 24.5 Ca, 24.5Na, 6.0P w/v%). PEO-BG enhanced Ti mechanical and tribological properties with higher corrosion resistance. Furthermore, PEO-BG had a positive influence in polymicrobial biofilms, by reducing pathogenic bacterial associated with biofilm-related infections. PEO-BG also showed higher adsorption of blood plasma proteins without cytotoxic effects on human cells, and thus may be considered a promising biocompatible approach for biomedical implants.



中文翻译:

通过等离子电解氧化合成生物活性玻璃基涂层:揭开通往钛植入物表面的新沉积路径。

假设

尽管以前已经通过不同的方法开发了生物活性玻璃(BG)颗粒涂层,但是由于玻璃结晶,颗粒对表面的附着力差以及生物学效应降低,限制了其生物医学应用。为了克服这个问题,我们首次将等离子电解氧化(PEO)作为一种在钛(Ti)材料上合成生物活性玻璃基涂层(PEO-BG)的新途径。

实验

生物活性元素电解质溶液(钠2的SiO 3 -5H 2 O,C 4 H ^ 6 ø 4的Ca,纳米3,和C 3 ħ 7的Na 2 ö 6 P)被用作前体源以获得45S5 bioglass-PEO在Ti表面的组成。随后,与机械加工和喷砂/酸蚀控制表面相比,研究了PEO-BG涂层的表面,机械,摩擦学,电化学,微生物学和生物学特性。

发现

PEO处理产生的涂层具有类似于45S5-BG(〜45.0Si,24.5 Ca,24.5Na,6.0P w / v%)的复杂表面形貌,Ti晶相,超亲水状态,化学组成和氧化物层。PEO-BG增强了Ti的机械和摩擦学性能,并具有更高的耐腐蚀性。此外,PEO-BG通过减少与生物膜相关感染相关的致病细菌,对微生物生物膜具有积极影响。PEO-BG还显示出更高的血浆蛋白吸附能力,而对人体细胞无细胞毒性作用,因此,PEO-BG被认为是一种有前途的生物医学植入物生物相容性方法。

更新日期:2020-07-08
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