Rational spatiotemporal irradiation of cellulose-based hydrogels (carboxymethylcellulose (CMC), citric acid, and riboflavin) using a laser diode stereolithography 3D printer obtained architectures referred to as photodegradation addressable hydrogels (PAHs). Under irradiation, these PAHs engage in an unprecedented spatially resolved zonal swelling illustrating marked but controllable changes in swelling and thickness while concomitantly obtaining improved oxygen transmission rate values by 5 times. XPS, carboxyl content, and swelling data comparisons of hydrogel formulations show that photodegradation and ablation of the material occur, where hydroxyl sites of CMC are converted to aldehydes and ketones. XRD data show that the total number of crystalline aggregates in the material are lowered after photoablation. The spatially tuned (photoablated) hydrogel films can thus be shaped into a lens form. The energy required for the lens tuning process can be lowered up to 30 times by incorporation of riboflavin in the films. The method demonstrated here enables the processing of a material that is difficult to be machined or cast by popular contact lens making methods.

中文翻译：

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用于制造生物医学装置的纤维素基水凝胶的 3D 光诱导时空分辨率

使用激光二极管立体光刻 3D 打印机对基于纤维素的水凝胶（羧甲基纤维素 (CMC)、柠檬酸和核黄素）进行合理的时空照射，获得了称为光降解可寻址水凝胶 (PAH) 的结构。在辐照下，这些 PAHs 会发生前所未有的空间分辨带状膨胀，说明膨胀和厚度发生显着但可控的变化，同时氧气透过率值提高了 5 倍。水凝胶配方的 XPS、羧基含量和溶胀数据比较表明，材料发生光降解和烧蚀，其中 CMC 的羟基位点转化为醛和酮。XRD 数据显示，光烧蚀后材料中结晶聚集体的总数降低。空间调谐（光烧蚀）水凝胶膜因此可以成形为透镜形式。通过在薄膜中加入核黄素，可以将镜片调谐过程所需的能量降低多达 30 倍。此处演示的方法能够处理通过流行的隐形眼镜制造方法难以加工或铸造的材料。