Allicin is a natural product suppressing the progression of gastric carcinoma (GC). In the current study, the mechanism underlying the anti-GC effect of allicin was explored by focusing on the role of miR-383-5p/ERBB4 signaling. Two GC cell lines were treated with allicin and the effects on viability, apoptosis, migration, invasion, and miR-383-5p/ERBB4 activity in the cells were assessed. The interaction between allicin and miR-383-5p was further explored by inhibiting the miR-383-5p level. Allicin suppressed cell viability and induced apoptosis in both GC cell lines. The compound also inhibited migration and invasion of GC cells, which was associated with the up-regulation miR-383-5p and down-regulation of ERBB4. The inhibition of miR-383-5p by specific inhibitor blocked the anti-GC effect of allicin. Our results demonstrated that allicin contributed to the suppressed growth and metastasis potentials in GC cell lines. The effect was accompanied by an increased level of miR-383-5p and subsequent inhibition of ERBB4.

大蒜素是抑制胃癌（GC）进展的天然产物。在当前的研究中，通过关注miR-383-5p / ERBB4信号传导的作用，探索了大蒜素抗GC效应的潜在机制。用大蒜素处理了两个GC细胞系，并评估了其对细胞活力，凋亡，迁移，侵袭和miR-383-5p / ERBB4活性的影响。通过抑制miR-383-5p水平，进一步探索了大蒜素与miR-383-5p之间的相互作用。大蒜素抑制了两种GC细胞系的细胞活力并诱导了细胞凋亡。该化合物还抑制了GC细胞的迁移和侵袭，这与miR-383-5p的上调和ERBB4的下调有关。特定抑制剂对miR-383-5p的抑制作用可阻断大蒜素的抗GC作用。我们的结果表明，大蒜素有助于抑制GC细胞系的生长和转移潜力。该作用伴随着miR-383-5p水平的升高和随后对ERBB4的抑制。