The intracranial measurement of local cerebral tissue oxygen levels—PbtO₂—has become a useful tool for the critical care unit to investigate severe trauma and ischemia injury in patients. Our preliminary work in animal models supports the hypothesis that multi-site depth electrode recording of PbtO₂ may give surgeons and critical care providers needed information about brain viability and the capacity for better recovery. Here, we present a surface morphology characterization and an electrochemical evaluation of the analytical properties toward oxygen detection of an FDA-approved, commercially available, clinical grade depth recording electrode comprising 12 Pt recording contacts. We found that the surface of the recording sites is composed of a thin film of smooth Pt and that the electrochemical behavior evaluated by cyclic voltammetry in acidic and neutral electrolyte is typical of polycrystalline Pt surface. The smoothness of the Pt surface was further corroborated by determination of the electrochemical active surface, confirming a roughness factor of 0.9. At an optimal working potential of −0.6 V vs. Ag/AgCl, the sensor displayed suitable values of sensitivity and limit of detection for in vivo PbtO₂ measurements. Based on the reported catalytical properties of Pt toward the electroreduction reaction of O₂, we propose that these probes could be repurposed for multisite monitoring of PbtO₂ in vivo in the human brain.

中文翻译：

---

用于监测脑组织氧的多位临床深度记录电极的电化学评估。

颅内局部脑组织氧水平PbtO _2的测量已成为重症监护室调查患者严重创伤和局部缺血损伤的有用工具。我们在动物模型中的初步工作支持以下假设：多位深度电极记录PbtO ₂可能会为外科医生和重症监护提供者提供所需的有关脑活力和更好康复能力的信息。在这里，我们介绍了一个表面形态特征和对氧检测的FDA批准的，可商购的，临床级深度记录电极的分析性能的电化学评估，该药物包括12个Pt记录触点。我们发现记录位点的表面由光滑的Pt薄膜组成，并且通过循环伏安法在酸性和中性电解质中评估的电化学行为是多晶Pt表面的典型特征。通过确定电化学活性表面进一步证实了Pt表面的光滑度，确认粗糙度系数为0.9。在相对于Ag / AgCl的−0.6 V的最佳工作电势下，体内PbtO ₂测量。基于已报道的Pt对O ₂的电还原反应的催化特性，我们建议将这些探针重新用于人脑中体内PbtO _2的 多部位监测。