In these environmentally conscious days there is need to use eco‐friendly greener technologies, such as solvent free, microwave, ultrasound and use of room temperature. Here report an efficient and green protocol for the synthesis of 5‐aminopyrazole‐4‐carbonitrile from three component condensation of phenyl hydrazine, aldehyde, and malononitrile using NaPTS as catalyst in aqueous medium. Use of water has emerged as a versatile solvent for organic reaction; it is readily available, inexpensive, environmentally benign, neutral and natural solvent. Multicomponent reactions in water are of outstanding value in organic synthesis and green chemistry. The significant features of this article are short reaction time, provide excellent yield, removal of toxic solvent and use of water as green solvent.

中文翻译：

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甲苯-4-磺酸钠作为可重复使用的环保催化剂，可在水性介质中更绿色地合成5-氨基吡唑-4-腈

在这些具有环保意识的日子里，需要使用环保的绿色技术，例如无溶剂，微波，超声和使用室温。本文报告了在水性介质中使用NaPTS作为催化剂由苯基肼，醛和丙二腈的三组分缩合反应合成5-氨基吡唑-4-腈的有效而绿色的方案。使用水已成为有机反应的通用溶剂。它容易获得，便宜，对环境无害，中性和天然溶剂。水中的多组分反应在有机合成和绿色化学中具有卓越的价值。本文的显着特点是反应时间短，产率高，有毒溶剂的去除以及使用水作为绿色溶剂。