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Differential antibody responses to Giardia lamblia strain variants expressing dissimilar levels of an immunogenic protein.
Parasite Immunology ( IF 2.2 ) Pub Date : 2020-06-28 , DOI: 10.1111/pim.12767
Thania Garzon 1 , Lourdes Valencia 1 , Victor Dominguez 1 , Lucila Rascon 1 , Jael Quintero 2 , Adriana Garibay-Escobar 1 , Ramón Enrique Robles-Zepeda 1 , Carlos Velazquez 1
Affiliation  

Giardia lamblia is a protozoan parasite that causes giardiasis, one of the most common worldwide gastrointestinal diseases. For rational development of a Giardia vaccine, increasing our understanding of the host‐Giardia interaction is crucial. In this study, we analysed the immunogenicity and antigenicity of two G lamblia strain variants [GS and GS‐5G8 (+)], which express different levels of the variant‐specific surface protein (VSP) 5G8 and also analysed the intestinal histological changes associated with Giardia infection.

中文翻译:

对表达不同水平免疫原性蛋白质的贾第鞭毛虫兰氏菌株变异的抗体反应不同。

贾第鞭毛虫是一种原生动物寄生虫,可引起贾第鞭毛虫病,这是全球最常见的胃肠道疾病之一。为了合理开发贾第鞭毛虫疫苗,增加我们对宿主贾第鞭毛虫相互作用的了解至关重要。在这项研究中,我们分析了两种G兰姆利亚菌株变异体[GS和GS-5G8(+)]的免疫原性和抗原性,它们表达不同水平的变异体特异性表面蛋白(VSP)5G8,并分析了相关的肠道组织学变化与贾第鞭毛虫感染。
更新日期:2020-06-28
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