Being able to recognize red flags for neurodevelopmental disorders (NDD) is crucial to provide timely intervention programs. This work aims to support - within a scientific framework - the construction of an instrument capable to early detect all spectrum of NDD and explore all areas of development, detect failures in typical developmental pathways and point out atypical signs at all ages. This overview of reviews provides evidence for differences in children later diagnosed with NDD compared to typically developing peers such as delays in motor, language development and temperament in the first three years of age, repetitive/stereotyped behaviors, atypicalities/delays in play, object use, attention, visual, sensory processing and social engagement in the first and second year, and difficulties in feeding and sleeping in the first year. These behaviors must be carefully observed as potential red flags for NDD. However, data of the systematic reviews are not yet useful to develop an evidence-based clinical screening. It urges to increase efforts in producing systematic reviews on early behavioral markers for each NDD.

Trial registration:CRD42019137731.

(https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=137731).

能够识别神经发育障碍（NDD）的危险信号对于提供及时的干预计划至关重要。这项工作旨在在科学框架内支持一种仪器的构建，该仪器能够及早发现NDD​​的所有领域并探索所有的发展领域，发现典型的发展途径中的失败并指出各个年龄段的非典型症状。这篇综述概述为后来被诊断为NDD的儿童与通常发展中的同龄人之间的差异提供了证据，例如运动障碍，前三岁的语言发展和气质，重复/刻板的行为，非典型/游戏时延，玩物使用第一年和第二年的注意力，视觉，感觉处理和社交活动，以及第一年的进食和睡眠困难。这些行为必须作为NDD的潜在危险信号仔细观察。但是，系统评价的数据尚不能用于开展基于证据的临床筛查。它敦促加大力度，针对每个NDD对早期行为标记进行系统的审查。

试用注册：CRD42019137731。

（https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=137731）。