Despite the previously reported health benefits of calcium intake for the attenuation of metabolic disease, few studies have investigated the relationships among calcium intake, gut microbiota, and host metabolism. In this study, we assessed the effects of calcium supplementation on host microbial community composition and metabolic homeostasis. Mice were fed a high-fat diet with different calcium concentrations (4 and 12 g/kg) of 2 calcium supplements, calcium carbonate and calcium citrate. Supplementation with the higher concentration of calcium citrate significantly prevented body weight gain and decreased plasma biomarkers for metabolic disorder compared to calcium carbonate supplementation. Both calcium supplementation led to changes in microbial composition, increased propionate production and increased anorexigenic GLP-1 gene expression. The calcium citrate groups also experienced less metabolic endotoxemia. Our findings suggested that calcium supplementation could ameliorate host metabolic disorder caused by a high-fat diet, due to gut microbiota changes as well as decreased intestinal inflammation.

尽管先前报道了钙摄入对减轻代谢疾病的健康益处，但很少有研究调查钙摄入，肠道菌群和宿主代谢之间的关系。在这项研究中，我们评估了补充钙对宿主微生物群落组成和代谢稳态的影响。给小鼠饲喂高钙饮食，其中钙的浓度不同（分别为4和12 g / kg），2种钙补充剂，碳酸钙和柠檬酸钙。与补充碳酸钙相比，补充较高浓度的柠檬酸钙可显着防止体重增加，并减少代谢紊乱的血浆生物标志物。两种钙的补充均导致微生物组成的变化，丙酸酯产量的增加和厌食性GLP-1基因表达的增加。柠檬酸钙组的代谢性内毒素血症也较少。我们的研究结果表明，由于肠道菌群的变化以及肠道炎症的减少，钙的补充可以减轻高脂饮食引起的宿主代谢紊乱。