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Advances and opportunities for hiPSC-derived models of the blood-brain barrier
Current Opinion in Chemical Engineering ( IF 6.6 ) Pub Date : 2020-06-27 , DOI: 10.1016/j.coche.2020.05.006
Hannah S Seo , Pedram Motallebnejad , Samira M Azarin

As the interface between the vasculature and the central nervous system (CNS), the blood-brain barrier (BBB), composed of brain microvascular endothelial cells (BMECs), plays a crucial role in maintaining the health of the CNS but hinders drug delivery. Accordingly, in vitro modeling of the BBB has been and continues to be of great interest to scientists studying neurological diseases and developing therapeutics that must be delivered to the brain. The establishment of human induced pluripotent stem cell-derived BMECs (iBMECs) has addressed a major challenge of in vitro modeling of the BBB by providing a scalable source of BMECs that have key features of the in vivo BBB and facilitate disease-in-a-dish and BBB-on-a-chip applications. As researchers seek to augment the applicability of iBMECs for various studies, models involving iBMECs can be improved by integrating more elements of the in vivo BBB microenvironment.



中文翻译:

hiPSC衍生的血脑屏障模型的进展和机会

作为脉管系统和中枢神经系统(CNS)之间的接口,由脑微血管内皮细胞(BMEC)组成的血脑屏障(BBB)在维持CNS的健康但阻碍药物输送方面起着至关重要的作用。因此,对于BBB的体外建模一直以来,并且将继续引起研究神经系统疾病和开发必须输送到大脑的疗法的科学家的极大兴趣。人类诱导的多能干细胞源性BMEC(iBMEC)的建立通过提供具有体内关键特征的可扩展BMEC来源,解决了BBB体外建模的主要挑战。BBB并促进盘中疾病和BBB芯片应用。随着研究人员寻求增加iBMECs在各种研究中的适用性,可以通过整合体内BBB微环境的更多元素来改善涉及iBMECs的模型。

更新日期:2020-06-28
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