Purpose

Primary spinal cord glioblastoma (GBM) is a rare and devastating disease. Little attention was ever paid to this rare disease. As a result, the standard treatment protocol and prognostic factors of primary spinal cord GBM were not well established. The aim of this study was to determine the predictors associated with survival in patients with primary spinal cord GBM.

Methods

A total of 122 patients with primary spinal cord GBM from Surveillance, Epidemiology, and End Results database and our institution were included in this retrospective analysis. Information about age, sex, race, tumor invasion, extent of resection, radiation, chemotherapy and year of diagnosis was collected. Univariate and multivariate accelerated failure time (AFT) regression model was performed to identify prognostic factors.

Results

Of the 122 patients, 102 (83.6%) expired at the time of data collection. Overall survival at 1 year, 2 years, 3 years and 5 years was 48.4%, 22.8%, 17.1% and 8.4%, respectively, and median survival time was 12 months. Only radiation was found to be associated with survival in the AFT regression model (time ratio 1.94, 95% CI 1.01–3.72, p < 0.05). Radiotherapy could improve survival slightly; patients who received RT survived approximately two times as long as patients who did not receive RT, but the advantage was short term.

Conclusion

The survival of primary spinal cord GBM is poor in the current treatment strategy. Radiotherapy was associated with better survival, but the advantage was short term.

中文翻译：

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原发性脊髓胶质母细胞瘤患者死亡率的预测指标。

目的

原发性脊髓胶质母细胞瘤（GBM）是一种罕见的破坏性疾病。很少有人关注这种罕见的疾病。结果，原发性脊髓GBM的标准治疗方案和预后因素尚不明确。这项研究的目的是确定与原发性脊髓GBM患者生存相关的预测因子。

方法

回顾性分析包括来自监测，流行病学和最终结果数据库以及我们机构的总共122例原发性脊髓GBM患者。收集有关年龄，性别，种族，肿瘤浸润，切除范围，放射线，化学疗法和诊断年份的信息。进行单因素和多因素加速失败时间（AFT）回归模型以鉴定预后因素。

结果

在122名患者中，有102名（83.6％）在数据收集时死亡。1年，2年，3年和5年的总生存率分别为48.4％，22.8％，17.1％和8.4％，中位生存时间为12个月。在AFT回归模型中，仅发现辐射与生存相关（时间比1.94，95％CI 1.01-3.72，p  <0.05）。放疗可以稍微改善生存率；接受逆转录疗法的患者生存时间是未接受逆转录疗法的患者的两倍，但优势是短期的。

结论

在目前的治疗策略中，原发性脊髓GBM的存活率较差。放疗与更好的生存率相关，但优势是短期的。