Simulated moving bed chromatography process, which is a multicolumn chromatography process, has been used in various industrial applications. Dynamic axial compression columns are key elements in simulated moving beds, and their flow characteristics are worth exploring using state-of-the-art numerical methodologies. In this study, new fluid distributors for the dynamic axial compression column were designed and fabricated based on mass conservation in fluid mechanics and the computer-aided design in the preliminary stage. Computational fluid dynamics was employed to resolve the flow field, and the numerical chromatograms were validated by laboratory experiments. For the computational fluid dynamics–based simulation of flow in the dynamic axial compression, the transient laminar flow fields were described by the momentum and species transport equations with Darcy’s law to model the porous zone in the packed bed. In addition, reverse engineering processes were applied to obtain the unknown physical parameters, such as viscous resistance and adsorption equilibrium coefficients. Moreover, including the adsorption equilibrium equation in the fundamental governing equations made the simulated results agree with the experimental data in chromatograms, providing a more feasible result for practical applications.

模拟移动床色谱法是一种多柱色谱法，已用于各种工业应用中。动态轴向压缩柱是模拟移动床中的关键要素，其流动特性值得使用最新的数值方法进行探讨。在这项研究中，基于流体力学中的质量守恒和初期阶段的计算机辅助设计，设计并制造了用于动态轴向压缩柱的新型流体分配器。使用计算流体动力学来解析流场，并通过实验室实验验证了数字色谱图。对于基于计算流体动力学的动态轴向压缩中的流动模拟，用达西定律通过动量和物种迁移方程描述了瞬态层流场，以模拟填充床中的多孔区域。另外，逆向工程过程被用于获得未知的物理参数，例如粘性阻力和吸附平衡系数。此外，在基本控制方程中包含吸附平衡方程，使模拟结果与色谱实验数据吻合，为实际应用提供了更为可行的结果。