当前位置: X-MOL 学术Environ. Sci. Technol. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Effect-Based Identification of Hazardous Antibiotic Transformation Products after Water Chlorination.
Environmental Science & Technology ( IF 11.4 ) Pub Date : 2020-06-26 , DOI: 10.1021/acs.est.0c00944
Adrián Jaén-Gil 1, 2 , María-José Farré 1, 2 , Alexandre Sànchez-Melsió 1, 2 , Albert Serra-Compte 1, 2 , Damià Barceló 1, 2, 3 , Sara Rodríguez-Mozaz 1, 2
Affiliation  

Antibiotic transformation products (TPs) generated during water treatment can be considered as an environmental concern, since they can retain part of the bioactivity of the parent compound. Effect-directed analysis (EDA) was applied for the identification of bioactive intermediates of azithromycin (AZI) and ciprofloxacin (CFC) after water chlorination. Fractionation of samples allowed the identification of bioactive intermediates by measuring the antibiotic activity and acute toxicity, combined with an automated suspect screening approach for chemical analysis. While the removal of AZI was in line with the decrease of bioactivity in chlorinated samples, an increase of bioactivity after complete removal of CFC was observed (at >0.5 mgCl2/L). Principal component analysis (PCA) revealed that some of the CFC intermediates could contribute to the overall toxicity of the chlorinated samples. Fractionation of bioactive samples identified that the chlorinated TP296 (generated from the destruction of the CFC piperazine ring) maintained 41%, 44%, and 30% of the antibiotic activity of the parent compound in chlorinated samples at 2.0, 3.0, and 4.0 mgCl2/L, respectively. These results indicate the spectrum of antibacterial activity can be altered by controlling the chemical substituents and configuration of the CFC structure with chlorine. On the other hand, the potential presence of volatile DBPs and fractionation losses do not allow for tentative confirmation of the main intermediates contributing to the acute toxic effects measured in chlorinated samples. Our results encourage further development of new and advanced methodologies to study the bioactivity of isolated unknown TPs to understand their hazardous effects in treated effluents.

中文翻译:

水氯化后基于危险的有害抗生素转化产物的鉴定。

在水处理过程中产生的抗生素转化产物(TPs)可以视为环境问题,因为它们可以保留母体化合物的部分生物活性。效果导向分析(EDA)用于水氯化后阿奇霉素(AZI)和环丙沙星(CFC)的生物活性中间体的鉴定。通过对样品进行分级分离,可以通过测量抗生素活性和急性毒性并结合用于化学分析的自动可疑筛查方法来鉴定生物活性中间体。虽然AZI的去除与氯化样品中生物活性的降低是一致的,但在完全去除CFC之后观察到生物活性的增加(> 0.5 mgCl 2时)/ L)。主成分分析(PCA)表明,某些CFC中间体可能会导致氯化样品的整体毒性。对生物活性样品进行分级分离后发现,氯化的TP296(由CFC哌嗪环的破坏产生)在2.0、3.0和4.0 mgCl 2的条件下仍保持了氯化物样品中母体化合物的41%,44%和30%的抗生素活性。/ L。这些结果表明,可以通过控制氯的化学取代基和CFC结构的构型来改变抗菌活性的范围。另一方面,潜在的挥发性DBP和分馏损失的存在并不能初步确认导致氯化样品中急性毒性作用的主要中间体。我们的结果鼓励进一步开发新的和先进的方法,以研究分离的未知TP的生物活性,以了解其在处理后的废水中的有害作用。
更新日期:2020-07-21
down
wechat
bug