The high resolution of single-cell DNA sequencing (scDNA-seq) offers great potential to resolve intratumor heterogeneity (ITH) by distinguishing clonal populations based on their mutation profiles. However, the increasing size of scDNA-seq datasets and technical limitations, such as high error rates and a large proportion of missing values, complicate this task and limit the applicability of existing methods.

中文翻译：

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BnpC：单细胞突变谱的贝叶斯非参数聚类。

单细胞DNA测序（scDNA-seq）的高分辨率提供了巨大的潜力，可通过根据其突变谱区分克隆群体来解决肿瘤内异质性（ITH）。但是，scDNA-seq数据集的大小不断增加以及技术上的局限性（例如较高的错误率和大部分缺失值）使这项任务变得复杂，并限制了现有方法的适用性。