Inhibitory and stimulatory immune checkpoint molecules play important roles in regulating immune responses. An increasing number of these immune regulators are currently being evaluated as targets in putative anti-cancer therapies. Recently, sophisticated genetic screens have been performed to increase our understanding of immune checkpoint pathways and their immunomodulatory regulators. Here, we summarize novel insights obtained by these screens and discuss new directions to advance possible strategies to treat malignancies.

中文翻译：

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免疫检查点分子新型调节剂的遗传筛选。

抑制性和刺激性免疫检查点分子在调节免疫反应中起重要作用。目前正在评估越来越多的这些免疫调节剂作为推定的抗癌治疗的靶标。最近，已经进行了复杂的遗传筛选，以增加我们对免疫检查点途径及其免疫调节因子的了解。在这里，我们总结了通过这些屏幕获得的新颖见解，并讨论了新的方向，以推进治疗恶性肿瘤的可能策略。