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Microdosimetry with a 3D silicon on insulator (SOI) detector in a low energy proton beamline
Radiation Physics and Chemistry ( IF 2.9 ) Pub Date : 2020-11-01 , DOI: 10.1016/j.radphyschem.2020.109078 Andreas Tefre Samnøy , Kristian S. Ytre-Hauge , Eirik Malinen , Linh Tran , Anatoly Rosenfeld , Marco Povoli , Angela Kok , Anand Summanwar , Dieter Röhrich
Radiation Physics and Chemistry ( IF 2.9 ) Pub Date : 2020-11-01 , DOI: 10.1016/j.radphyschem.2020.109078 Andreas Tefre Samnøy , Kristian S. Ytre-Hauge , Eirik Malinen , Linh Tran , Anatoly Rosenfeld , Marco Povoli , Angela Kok , Anand Summanwar , Dieter Röhrich
Abstract Introduction An accurate description of the radiation quality of proton beams is a precondition to increase our understanding of radiobiological mechanisms and to develop accurate biological response models for radiotherapy. However, there are few detectors capable of measuring microdosimetric quantities with high spatial resolution along the entire Bragg curve due to the rapid increase in stopping power at the Bragg peak (BP) and distal dose fall-off (DDF). The aim of this work was to measure the microdosimetric spectra along the Bragg curve in a low energy proton beamline used for radiobiological experiments with a novel 3D silicon-on-insulator (SOI) “mushroom” microdosimeter. Method A silicon microdosimeter with an array of 3D structured diodes, creating well-defined sensitive volumes (SV) with excellent spatial resolution was used for microdosimetry. The microdosimeter was used to measure microdosimetric spectra and the relative dose throughout the Bragg curve of a 15 MeV proton beam by sequential insertion of 16 μm thick polyamide absorption films in front of the microdosimeter. The results were tissue corrected with a novel correction function and compared to Monte Carlo (MC) simulations performed in GATE. Results The measured dose-mean lineal energy ( y D ‾ ) increased from 8 keV/μm at the entrance to 24 keV/μm at the BP, rising to a maximum of 35 keV/μm at the DDF. The measured y D ‾ showed an overall good agreement with the MC simulated values, with deviation of less than 2% at the BP and DDF, while the largest deviation (12%) was found at the entrance. Clear changes in microdosimetric spectra were seen for each 16 μm step at the BP and DDF. Conclusion The SOI microdosimeter with its well-defined 3D sensitive volumes is an excellent tool for characterizing low energy beamlines that demands very high spatial resolution. The good overall agreement between experimental and simulated results indicated that the detector is capable of accurate microdosimetric measurements.
中文翻译:
在低能质子束线中使用 3D 绝缘体上硅 (SOI) 探测器进行微剂量测定
摘要 介绍准确描述质子束的辐射质量是增加我们对放射生物学机制的理解和开发准确的放射治疗生物反应模型的先决条件。然而,由于布拉格峰 (BP) 和远端剂量衰减 (DDF) 处的停止能力迅速增加,很少有探测器能够沿整个布拉格曲线以高空间分辨率测量微剂量量。这项工作的目的是使用新型 3D 绝缘体上硅 (SOI)“蘑菇”微剂量计测量用于放射生物学实验的低能质子束线中沿布拉格曲线的微剂量光谱。方法 具有 3D 结构二极管阵列的硅微剂量计,创建具有出色空间分辨率的明确定义的敏感体积 (SV) 用于微剂量测定。通过在微剂量计前面连续插入 16 μm 厚的聚酰胺吸收膜,微剂量计用于测量微剂量光谱和整个 15 MeV 质子束布拉格曲线的相对剂量。结果用新的校正函数进行了组织校正,并与在 GATE 中执行的蒙特卡罗 (MC) 模拟进行了比较。结果测得的剂量平均线性能量 (y D ‾ ) 从入口处的 8 keV/μm 增加到 BP 处的 24 keV/μm,在 DDF 处上升到最大值 35 keV/μm。测得的 y D ‾ 总体上与 MC 模拟值一致,BP 和 DDF 的偏差小于 2%,而最大偏差 (12%) 出现在入口处。在 BP 和 DDF 处,每 16 μm 步长都可以看到微剂量光谱的明显变化。结论 具有明确定义的 3D 敏感体积的 SOI 微剂量计是表征需要非常高空间分辨率的低能量光束线的绝佳工具。实验和模拟结果之间良好的总体一致性表明该检测器能够进行精确的微剂量测量。
更新日期:2020-11-01
中文翻译:
在低能质子束线中使用 3D 绝缘体上硅 (SOI) 探测器进行微剂量测定
摘要 介绍准确描述质子束的辐射质量是增加我们对放射生物学机制的理解和开发准确的放射治疗生物反应模型的先决条件。然而,由于布拉格峰 (BP) 和远端剂量衰减 (DDF) 处的停止能力迅速增加,很少有探测器能够沿整个布拉格曲线以高空间分辨率测量微剂量量。这项工作的目的是使用新型 3D 绝缘体上硅 (SOI)“蘑菇”微剂量计测量用于放射生物学实验的低能质子束线中沿布拉格曲线的微剂量光谱。方法 具有 3D 结构二极管阵列的硅微剂量计,创建具有出色空间分辨率的明确定义的敏感体积 (SV) 用于微剂量测定。通过在微剂量计前面连续插入 16 μm 厚的聚酰胺吸收膜,微剂量计用于测量微剂量光谱和整个 15 MeV 质子束布拉格曲线的相对剂量。结果用新的校正函数进行了组织校正,并与在 GATE 中执行的蒙特卡罗 (MC) 模拟进行了比较。结果测得的剂量平均线性能量 (y D ‾ ) 从入口处的 8 keV/μm 增加到 BP 处的 24 keV/μm,在 DDF 处上升到最大值 35 keV/μm。测得的 y D ‾ 总体上与 MC 模拟值一致,BP 和 DDF 的偏差小于 2%,而最大偏差 (12%) 出现在入口处。在 BP 和 DDF 处,每 16 μm 步长都可以看到微剂量光谱的明显变化。结论 具有明确定义的 3D 敏感体积的 SOI 微剂量计是表征需要非常高空间分辨率的低能量光束线的绝佳工具。实验和模拟结果之间良好的总体一致性表明该检测器能够进行精确的微剂量测量。