Food, Drug, & Cosmetic (FD&C) dyes are synthetic color additives used in food, prescription drugs and over-the-counter medicines (OTCs). Consumption of FD&C dyes has been associated with neurobehavioral behavior in some children. The amount of dye used in commercial products is proprietary, making it difficult to assess dietary intake and determine exposure in children. To date, no studies have examined FD&C dyes in OTCs or vitamins in the United States. To address this, FD&C Red No. 40, Yellow No. 5, Yellow No. 6, Blue No. 1, and Blue No. 2 levels were measured in prenatal vitamin tablets, children's chewable and gummy vitamins, pain reliever tablets and syrups, and cough/cold/allergy tablets and syrups. Dyes were isolated using solid phase extraction (SPE) and quantified by high performance liquid chromatography (HPLC). Dye levels varied between products with highest levels in pain reliever and cough/cold/allergy syrups. Significant variability was observed within some brands. Degradation of Red No. 40, Blue No. 1, and Yellow No. 6 was observed in the vitamin gummies. Intake of FD&C Red No. 40 is two times the US FDA ADI (accepted daily intake) for some children's pain reliever syrups and almost three times the US FDA ADI for some cough/cold/allergy syrups.

食品，药品和化妆品（FD＆C）染料是用于食品，处方药和非处方药（OTC）的合成色添加剂。食用FD＆C染料与某些儿童的神经行为有关。商业产品中使用的染料量是专有的，因此很难评估饮食摄入量和确定儿童的接触量。迄今为止，在美国，尚无任何研究检查非处方药或维生素中的FD＆C染料。为解决此问题，在产前维生素片，儿童咀嚼和软糖维生素，止痛片和糖浆中测量了FD＆C红色40号，黄色5号，黄色6号，蓝色1号和蓝色2号的含量，以及咳嗽/感冒/过敏药和糖浆。使用固相萃取（SPE）分离染料，并通过高效液相色谱（HPLC）进行定量。止痛药和止咳/感冒/过敏药水中的最高含量的产品之间的染料水平不同。在某些品牌中观察到明显的差异。在维生素胶中观察到红色40号，蓝色1号和黄色6号的降解。对于某些儿童止痛糖浆，FD＆C红色40号的摄入量是美国FDA ADI（每日允许摄入量）的两倍，而对于某些咳嗽/感冒/过敏糖浆的摄入量几乎是美国FDA ADI的三倍。