Objective

In the context of minimally invasive dentistry and tissue conservation, bioactive products are valuable. The aim of this review was to identify, clarify, and classify the methodologies used to quantify the bioactive glasses bioactivity.

Methods

Specific search strategies were performed in electronic databases: PubMed, Embase, Cochrane Library, and Scopus. Papers were selected after a review of their title, abstract, and full text. The following data were then examined for final selection: BAG investigated, objectives, criteria, methods, and outcomes.

Results

Sixty-one studies published from 2001 to 2019, were included. The bioactivity of BAG can be evaluated in vitro in contact with solutions, enamel, dentin, or cells. Other studies have conducted in vivo evaluation by BAG contact with dentin and dental pulp. Studies have used various analysis techniques: evaluation of apatite with or without characterization or assessment of mechanical properties. Reprecipitation mechanisms and pulp cell stimulation are treated together through the term ‘bioactivity’.

Significance

Based on these results, we suggested a classification of methodologies for a better understanding of the bioactive properties of BAG. According to all in vitro studies, BAG appear to be bioactive materials. No consensus has been reached on the results of in vivo studies, and no comparison has been conducted between protocols to assess the bioactivity of other bioactive competitor products.

中文翻译：

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牙科用生物活性玻璃的生物活性评估：一项重要评论。

目的

在微创牙科和组织保护的背景下，生物活性产品很有价值。这篇综述的目的是识别，澄清和分类用于量化生物活性玻璃生物活性的方法。

方法

在电子数据库中执行了特定的搜索策略：PubMed，Embase，Cochrane Library和Scopus。论文的标题，摘要和全文均经过审查后才被选中。然后检查以下数据以进行最终选择：调查的BAG，目标，标准，方法和结果。

结果

纳入2001年至2019年发表的61篇研究。BAG的生物活性可以在与溶液，牙釉质，牙本质或细胞接触的条件下进行体外评估。其他研究通过与牙本质和牙髓的BAG接触进行了体内评估。研究使用了各种分析技术：评估磷灰石的有无特征或评估机械性能。再沉淀机制和牙髓细胞刺激通过术语“生物活性”一起处理。

意义

基于这些结果，我们建议对方法进行分类，以更好地了解BAG的生物活性。根据所有体外研究，BAG似乎是生物活性物质。关于体内研究的结果尚未达成共识，并且在评估其他生物活性竞争产品的生物活性的方案之间也没有进行比较。