In this study, coenzyme A (CoA)-based coordination polymers (CPs) have been generated in situ by exploiting the reaction of thiols with metal ion (Au(III) or Ag(I)), which are dependent on both thiol-metal and aurophilic metal∙metal interaction. It is interesting to note that CPs-related biosensing capabilities toward some biomolecules including ascorbic acid (AA), cysteine (Cys) and glutathione (GSH) are also investigated via SYBR Green II (SGII)-derived fluorescence switchable mechanisms. The synthesized CPs display especial RNA-like structure and are capable of initiating the fluorescence of SGII. Conversely, AA, Cys or GSH can give rise to the structural destruction of RNA-like CPs, thus inhibiting the fluorescence signal, and quantitative detection of these biomolecules are achieved favorably with a detection limit of 7.2, 0.55 and 0.48 nM, respectively. Meanwhile, the fascinating fluorescence on-off property and simple synthetic process are employed to build a series of basic logic gates (YES, NOT, OR, AND, INHIBIT and NOR) and multiple configurable logic gates (OR-AND and OR-OR-INHIBIT) along with different logic inputs. In view of these, developing CoA-based CPs as a new material to execute logic operations provides a valuable platform to establish the next generation of advanced molecular devices for clinic diagnostic and biomedical research.

在这项研究中，原位产生了基于辅酶A（CoA）的配位聚合物（CPs）通过利用硫醇与金属离子（Au（III）或Ag（I））的反应，金属离子既依赖于硫醇-金属相互作用，又依赖于嗜金金属∙金属相互作用。有趣的是，还通过SYBR Green II（SGII）衍生的荧光转换机制研究了CPs对某些生物分子的生物传感能力，包括抗坏血酸（AA），半胱氨酸（Cys）和谷胱甘肽（GSH）。合成的CP显示出特别的RNA样结构，并且能够引发SGII的荧光。相反，AA，Cys或GSH会引起RNA样CP的结构破坏，从而抑制了荧光信号，并且分别以7.2、0.55和0.48 nM的检测限实现了对这些生物分子的定量检测。与此同时，迷人的荧光开关特性和简单的合成过程被用来构建一系列基本逻辑门（是，非，或，与，抑制和或非）和多个可配置逻辑门（或-与和或或-或-抑制）以及不同的逻辑输入。有鉴于此，开发基于CoA的CP作为执行逻辑运算的新材料提供了一个宝贵的平台，可以建立用于临床诊断和生物医学研究的下一代高级分子设备。