Anorexia nervosa, with the highest mortality rate among psychiatric diseases, is characterized by low body mass index, fear of weight gain, and disturbed body image. Even though multiple drugs have been proposed for the treatment of anorexia nervosa, current treatment modalities include nutritional support and psychotherapy. In this study, our aim is to analyze the efficiency and possible adverse effects of olanzapine, an atypical anti-psychotic drug, in the treatment of anorexia nervosa. The studies investigating the efficiency and possible adverse effects of olanzapine in anorexia nervosa have been searched by using 3 databases (Embase, PubMed, and Cochrane Library). DerSimonian-Laird random effects meta-analyses have been used in the statistical analysis. Effect of olanzapine treatment in accordance with the duration and dosage of drug have been analyzed by the determination of 95% confidence intervals ( p value < 0.05 is considered as statistically significant). Despite the presence of some contradictory studies, olanzapine treatment has been found beneficial in anorexia nervosa. In addition, analysis reveals that statistically significant beneficial effect of olanzapine treatment is used at high doses and for short duration. Possible side effects include neuroleptic malignant syndrome, hypoglycemia, and heart block in patients suffering from anorexia nervosa. Even though there is obvious need for more comprehensive further studies, current literature favors olanzapine treatment. The efficiency of olanzapine is considered to be related to changes in dopaminergic and serotonergic system in anorexic patients both in terms of neurotransmitter levels and receptor activity.

中文翻译：

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奥氮平治疗神经性厌食症：系统评价

神经性厌食症是精神疾病中死亡率最高的一种，其特点是体重指数低、害怕体重增加、身体形象紊乱。尽管已经提出多种药物来治疗神经性厌食症，但目前的治疗方式包括营养支持和心理治疗。在本研究中，我们的目的是分析奥氮平（一种非典型抗精神病药物）治疗神经性厌食症的有效性和可能的​​不良反应。已使用 3 个数据库（Embase、PubMed 和 Cochrane 图书馆）检索了调查奥氮平治疗神经性厌食症的有效性和可能的​​不良反应的研究。DerSimonian-Laird 随机效应荟萃分析已用于统计分析。通过确定 95% 置信区间（p 值 < 0.05 被认为具有统计学意义）分析了根据药物持续时间和剂量的奥氮平治疗效果。尽管存在一些相互矛盾的研究，但已发现奥氮平治疗对神经性厌食症有益。此外，分析表明，奥氮平治疗在高剂量和短期内使用具有统计学意义的有益效果。可能的副作用包括神经性厌食症患者的抗精神病药恶性综合征、低血糖和心脏传导阻滞。尽管显然需要更全面的进一步研究，但目前的文献支持奥氮平治疗。