We developed a mitochondrion-targeting Mn^II-terpyridine complex (MTP) for two-photon photodynamic therapy. MTP was subjected to two-photon excitation in the NIR region to generate ¹O₂ and hence produce a PDT effect. This use of MTP overcame the drawbacks of traditional PDT agents. The Mn^II center of MTP apparently catalyzed the H₂O₂-mediated production of ROS and oxygen, which subsequently promoted the ¹O₂ generation, furthering the PDT effect. Additionally, the mitochondrion targeting of MTP provided a good spatial condition for the generation of ¹O₂, which further promoted the PDT effect.

中文翻译：

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一种针对双光子光动力疗法的线粒体靶向Mn（ii）-吡啶化合物。

我们开发了针对双光子光动力疗法的线粒体靶向Mn ^II-吡啶复合物（MTP）。MTP在NIR区域受到两光子激发，产生¹ O ₂，因此产生PDT效应。MTP的这种使用克服了传统PDT代理的缺点。MTP的Mn ^II中心显然催化了H ₂ O ₂介导的ROS和氧的产生，随后促进了¹ O _2的产生，进一步促进了PDT的作用。此外，MTP的线粒体靶向为¹ O ₂的产生提供了良好的空间条件，进一步提升了PDT的效果。