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Discontinuing cannabis improves depression in people with multiple sclerosis: A short report
Multiple Sclerosis Journal ( IF 5.8 ) Pub Date : 2020-06-26 , DOI: 10.1177/1352458520934070
Anthony Feinstein 1 , Cecilia Meza 1 , Cristiana Stefan 2 , W Richard Staines 3
Affiliation  

To assess whether symptoms of depression change when people with multiple sclerosis (pwMS) discontinue cannabis use, 40 cognitively impaired pwMS who smoked cannabis almost daily were randomly assigned to either a cannabis continuation (CC) or cannabis withdrawal (CW) group. Both groups were followed for 28 days. All participants completed the Hospital Anxiety and Depression Scale. At day 28 the 11-nor-9-carboxy-Δ9-tetrahydro-cannabinol (THCCOOH)/creatinine ratio in the CW group declined to zero (p = 0.0001), but remained unchanged in the CC group (p = 0.709). Depression scores in those pwMS who were using cannabis to manage their depression remained statistically unchanged in the CC group, but declined in the CW group (p = 0.006). Despite pwMS using cannabis to help their mood, depression improved significantly off the drug. Our finding provides a cautionary note in relation to cannabis use in pwMS, at least with respect to depression.

中文翻译:

停用大麻可改善多发性硬化症患者的抑郁症:一份简短报告

为了评估多发性硬化症 (pwMS) 患者停止使用大麻时抑郁症状是否发生变化,40 名几乎每天都吸食大麻的认知障碍 pwMS 被随机分配到大麻继续 (CC) 或大麻戒断 (CW) 组。两组均随访28天。所有参与者都完成了医院焦虑和抑郁量表。在第 28 天,CW 组的 11-nor-9-羧基-Δ9-四氢大麻酚 (THCCOOH)/肌酐比率下降至零 (p = 0.0001),但 CC 组保持不变 (p = 0.709)。使用大麻来治疗抑郁症的那些 pwMS 的抑郁症评分在 CC 组中在统计上保持不变,但在 CW 组中下降(p = 0.006)。尽管 pwMS 使用大麻来改善他们的情绪,但在服用药物后抑郁症得到了显着改善。
更新日期:2020-06-26
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