Aims: Currently, limited antibiotics are available to treat methicillin-resistant Staphylococcus aureus (MRSA) infections. One approach is the use of adjuvants in antibiotic therapy. 1,4-Naphthoquinones are naturally occurring alkaloids shown to have antibacterial properties. The objective of this study is to investigate the synergy between 1,4-naphthoquinone and selected β-lactam antibiotics and to evaluate the potential use of 1,4-naphthoquinone as an adjuvant in antibiotic treatment against MRSA infections.

中文翻译：

---

1,4-萘醌和β-内酰胺抗生素对耐甲氧西林金黄色葡萄球菌的协同抗菌活性

目的：目前，可用于治疗耐甲氧西林金黄色葡萄球菌(MRSA) 感染的抗生素有限。一种方法是在抗生素治疗中使用佐剂。1,4-萘醌是天然存在的生物碱，具有抗菌特性。本研究的目的是调查 1,4-萘醌和选定的 β-内酰胺抗生素之间的协同作用，并评估 1,4-萘醌作为抗生素治疗 MRSA 感染的辅助剂的潜在用途。