Abstract

The inhibition of renin angiotensin system pathway has been largely documented to be effective in the control of cardiovascular events. The present study investigated the effect of angiotensin converting enzyme (ACE) inhibitor on fasting blood glucose level in hypertension induced by the inhibition of nitric oxide synthase (NOS) in male Wistar rats. Hypertension was induced by the inhibition of NOS using a non-selective NOS inhibitor, NG-nitro-L-arginine methyl ester (L-NAME). The blockade of NOS resulted in an increase in blood pressure, ACE, angiotensin II and endothelin-1 levels, and a decrease in fasting blood glucose and nitric oxide (NO) levels. The hypertensive rats treated with ACE inhibitor (ramipril) recorded a decrease in blood pressure, ACE, angiotensin II, endothelin-1, NO and fasting blood glucose levels, and an increase in prostacyclin level. In conclusion, ACE inhibitor potentiated the hypoglycaemic effect of NOS inhibitor and this effect is independent of NO and pancreatic insulin release.

摘要

肾素血管紧张素系统通路的抑制已被大量证明可有效控制心血管事件。本研究调查了血管紧张素转化酶 (ACE) 抑制剂对抑制雄性 Wistar 大鼠一氧化氮合酶 (NOS) 诱导的高血压患者空腹血糖水平的影响。使用非选择性 NOS 抑制剂 NG-硝基-L-精氨酸甲酯 (L-NAME) 抑制 NOS 可诱发高血压。NOS 的阻断导致血压、ACE、血管紧张素 II 和内皮素-1 水平升高，空腹血糖和一氧化氮 (NO) 水平降低。用 ACE 抑制剂（雷米普利）治疗的高血压大鼠记录了血压、ACE、血管紧张素 II、内皮素-1、NO 和空腹血糖水平的下降，和增加前列环素水平。总之，ACE 抑制剂增强了 NOS 抑制剂的降血糖作用，这种作用与 NO 和胰腺胰岛素释放无关。