Abstract {La(pytza)3(H2O)2·2H2O}n derived from 5-(4-pyridyl)tetrazole-2-acetic acid (Hpytza) has been synthesized by a solvothermal reaction of Hpytza and La(NO3)3·6H2O. In this compound, neighboring La3+ ions are doubly bridged by two pytza ligands in a μ1,3-COO syn-syn mode to form a binuclear unit, then adjacent binuclear units are doubly bridged to give a 1-D ladder-like chain. In vitro MTT assay on HeLa cells demonstrates that Hpytza is nontoxic while {La(pytza)3(H2O)2·2H2O}n has a low half inhibitory concentration (IC50) of 18.2 μg/mL. Furthermore, cell migration across a 2-D artificial gap indicates that this compound can effectively inhibit the migration of HeLa cells, suggesting its potential to interfere with the tumor metastasis in vivo. Graphical Abstract

中文翻译：

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新型La(III)配位聚合物的合成及体外抗癌特性

摘要 {La(pytza)3(H2O)2·2H2O}n来源于5-(4-吡啶基)四唑-2-乙酸(Hpytza)，通过Hpytza和La(NO3)3·6H2O的溶剂热反应合成. 在该化合物中，相邻的 La3+ 离子通过两个 pytza 配体以 μ1,3-COO syn-syn 模式双桥接形成双核单元，然后相邻的双核单元双桥接形成一维梯状链。HeLa 细胞的体外 MTT 测定表明 Hpytza 是无毒的，而 {La(pytza)3(H2O)2·2H2O}n 具有 18.2 μg/mL 的低半抑制浓度 (IC50)。此外，跨二维人工间隙的细胞迁移表明该化合物可以有效抑制 HeLa 细胞的迁移，表明其具有干扰体内肿瘤转移的潜力。图形概要