In this study, the spectroscopic methods (UV–vis, fluorimetric), Atomic force microscopy, and computational studies (molecular docking and molecular dynamic simulation) were used to investigate the interaction of [SnMe₂Cl₂(Me₂phen)] complex with CT-DNA in the presence of glucose. The results showed the complex in the medium containing glucose has less effect on calf thymus DNA (ct-DNA) than the medium without glucose. Cytotoxicity of [SnMe₂Cl₂(Me₂phen)] complex on MCF-7 cells was examined and showed Sn(IV) complex possesses potential cytotoxicity against this cell line. Molecular docking study showed that Sn(IV) complex interacts with DNA by groove binding mode. Radius of gyration (Rg) was smaller upon binding of the Sn(IV) complex suggesting a more compact structure of DNA in the presence of Sn(IV) complex.

Communicated by Ramaswamy H. Sarma

在这项研究中，使用光谱学方法（紫外-可见，荧光法），原子力显微镜和计算研究（分子对接和分子动力学模拟）研究了[SnMe ₂ Cl ₂（Me ₂ phen）]络合物与葡萄糖存在下的CT-DNA。结果表明，与不含葡萄糖的培养基相比，含葡萄糖的培养基对小牛胸腺DNA（ct-DNA）的影响较小。[SnMe ₂ Cl ₂（Me ₂检查了MCF-7细胞上的复合物，并发现Sn（IV）复合物对该细胞系具有潜在的细胞毒性。分子对接研究表明，Sn（IV）配合物通过凹槽结合模式与DNA相互作用。当结合Sn（IV）复合物时，回转半径（Rg）较小，这表明在Sn（IV）复合物存在下，DNA的结构更为紧凑。

由Ramaswamy H.Sarma沟通