Circular (circ)RNAs influence a wide range of biological processes at least in part by interacting with proteins and microRNAs. CircRNAs expressed in the hematopoietic compartment have been increasingly recognized as modulators of physiological and pathological features of hematopoetic stem cell (HSC)-derived populations. In particular, several circRNAs were found to enhance or suppress tumor progression in blood malignancies such as leukemias and lymphomas. Moreover, numerous circRNAs have been proposed to help confer resistance to the conventional treatments used in hematopoietic cancers. Here, we review the most important circRNAs described thus far in acute myeloid leukemia (AML), chronic myeloid leukemia (CML), acute lymphoblastic leukemia (ALL), chronic lymphocytic leukemia (CLL), lymphomas, and multiple myeloma (MM). We discuss the usefulness of circRNAs as diagnostic and prognostic markers and their potential value as therapeutic targets.

环状（circ）RNA至少部分通过与蛋白质和microRNA相互作用来影响广泛的生物学过程。在造血区室表达的CircRNA已被越来越多地视为造血干细胞（HSC）衍生种群的生理和病理特征的调节剂。特别是，发现了几种circRNA在血液恶性肿瘤（如白血病和淋巴瘤）中增强或抑制肿瘤的进展。此外，已经提出了许多circRNA以帮助赋予对造血癌中使用的常规治疗的抗性。在这里，我们回顾了迄今为止在急性髓细胞性白血病（AML），慢性粒细胞性白血病（CML），急性淋巴细胞性白血病（ALL），慢性淋巴细胞性白血病（CLL），淋巴瘤和多发性骨髓瘤（MM）中描述的最重要的circRNA。