Purpose This study aimed to investigate the spectral and spatial signatures of neuromagnetic activity underlying the termination of absence seizures. Methods Magnetoencephalography (MEG) data were recorded from 18 drug-naive patients with childhood absence epilepsy (CAE). Accumulated source imaging (ASI) was used to analyze MEG data at the source level in seven frequency ranges: delta (1–4 Hz), theta (4–8 Hz), alpha (8–12 Hz), beta (12–30 Hz), gamma (30–80 Hz), ripple (80–250 Hz), and fast ripple (250–500 Hz). Result In the 1–4, 4–8, and 8–12 Hz ranges, the magnetic source during seizure termination appeared to be consistent over the ictal period and was mainly localized in the frontal cortex (FC) and parieto-occipito-temporal junction (POT). In the 12–30 and 30–80 Hz ranges, a significant reduction in source activity was observed in the frontal lobe during seizure termination as well as a decrease in peak source strength. The ictal peak source strength in the 1–4 Hz range was negatively correlated with the ictal duration of the seizure, whereas in the 30–80 Hz range, it was positively correlated with the course of epilepsy. Conclusion The termination of absence seizures is associated with a dynamic neuromagnetic process. Frequency-dependent changes in the FC were observed during seizure termination, which may be involved in the process of neural network interaction. Neuromagnetic activity in different frequency bands may play different roles in the pathophysiological mechanism during absence seizures.

中文翻译：

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失神癫痫发作终止的皮层神经磁活动的多频动力学

目的 本研究旨在研究终止失神发作的神经磁活动的光谱和空间特征。方法 记录 18 名儿童失神癫痫 (CAE) 未用药患者的脑磁图 (MEG) 数据。累积源成像 (ASI) 用于在七个频率范围内分析源级的 MEG 数据：delta (1-4 Hz)、theta (4-8 Hz)、alpha (8-12 Hz)、beta (12-30 Hz)、伽马 (30–80 Hz)、纹波 (80–250 Hz) 和快速纹波 (250–500 Hz)。结果 在 1-4、4-8 和 8-12 Hz 范围内，癫痫发作终止期间的磁源在发作期似乎是一致的，主要位于额叶皮层 (FC) 和顶枕颞交界处（锅）。在 12–30 和 30–80 Hz 范围内，在癫痫发作终止期间，在额叶中观察到源活动显着减少，并且峰值源强度降低。1-4 Hz 范围内的发作峰值源强度与癫痫发作的发作持续时间呈负相关，而在 30-80 Hz 范围内，它与癫痫病程呈正相关。结论 失神发作的终止与动态的神经磁过程有关。在癫痫发作终止期间观察到FC的频率依赖性变化，这可能参与了神经网络相互作用的过程。不同频段的神经磁活动可能在失神发作的病理生理机制中发挥不同的作用。1-4 Hz 范围内的发作峰值源强度与癫痫发作的发作持续时间呈负相关，而在 30-80 Hz 范围内，它与癫痫病程呈正相关。结论 失神发作的终止与动态的神经磁过程有关。在癫痫发作终止期间观察到FC的频率依赖性变化，这可能参与了神经网络相互作用的过程。不同频段的神经磁活动可能在失神发作的病理生理机制中发挥不同的作用。1-4 Hz 范围内的发作峰值源强度与癫痫发作的发作持续时间呈负相关，而在 30-80 Hz 范围内，它与癫痫病程呈正相关。结论 失神发作的终止与动态的神经磁过程有关。在癫痫发作终止期间观察到FC的频率依赖性变化，这可能参与了神经网络相互作用的过程。不同频段的神经磁活动可能在失神发作的病理生理机制中发挥不同的作用。在癫痫发作终止期间观察到FC的频率依赖性变化，这可能参与了神经网络相互作用的过程。不同频段的神经磁活动可能在失神发作的病理生理机制中发挥不同的作用。在癫痫发作终止期间观察到FC的频率依赖性变化，这可能参与了神经网络相互作用的过程。不同频段的神经磁活动可能在失神发作的病理生理机制中发挥不同的作用。